Epgo23_binary: Expected probability to do third phase III trial

In Sterniii3/drugdevelopR: Utility-Based Optimal Phase II/III Drug Development Planning

Expected probability to do third phase III trial

Description

In the setting of Case 2: Strategy 2/2( + 1); at least two trials significant (and the treatment effect of the other one at least showing in the same direction) this function calculates the probability that a third phase III trial is necessary.

Usage

Epgo23_binary(RRgo, n2, alpha, beta, p0, w, p11, p12, in1, in2)

Arguments

RRgo	threshold value for the go/no-go decision rule
n2	total sample size for phase II; must be even number
alpha	significance level
beta	1-beta power for calculation of sample size for phase III
p0	assumed true rate of control group
w	weight for mixture prior distribution
p11	assumed true rate of treatment group
p12	assumed true rate of treatment group
in1	amount of information for p11 in terms of sample size
in2	amount of information for p12 in terms of sample size

Value

The output of the function Epgo23_binary() is the probability to a third phase III trial.

Examples

res <- Epgo23_binary(RRgo = 0.8, n2 = 50,  p0 = 0.3, w = 0.3, alpha = 0.025, beta = 0.1,
                               p11 =  0.3, p12 = 0.5, in1 = 300, in2 = 600)

Sterniii3/drugdevelopR documentation built on Jan. 26, 2024, 6:17 a.m.