optimal_bias_generic: Generic function for optimizing drug development programs...

In Sterniii3/drugdevelopR: Utility-Based Optimal Phase II/III Drug Development Planning

Generic function for optimizing drug development programs with bias adjustment

Description

Generic function for optimizing drug development programs with bias adjustment

Usage

optimal_bias_generic(
  adj = "both",
  lambdamin = NULL,
  lambdamax = NULL,
  steplambda = NULL,
  alphaCImin = NULL,
  alphaCImax = NULL,
  stepalphaCI = NULL
)

Arguments

adj	choose type of adjustment: "multiplicative", "additive", "both" or "all". When using "both", res[1,] contains the results using the multiplicative method and res[2,] contains the results using the additive method. When using "all", there are also res[3,] and res[4,], containing the results of a multiplicative and an additive method which do not only adjust the treatment effect but also the threshold value for the decision rule.
lambdamin	minimal multiplicative adjustment parameter lambda (i.e. use estimate with a retention factor)
lambdamax	maximal multiplicative adjustment parameter lambda (i.e. use estimate with a retention factor)
steplambda	stepsize for the adjustment parameter lambda
alphaCImin	minimal additive adjustment parameter alphaCI (i.e. adjust the lower bound of the one-sided confidence interval)
alphaCImax	maximal additive adjustment parameter alphaCI (i.e. adjust the lower bound of the one-sided confidence interval)
stepalphaCI	stepsize for alphaCI

Sterniii3/drugdevelopR documentation built on Jan. 26, 2024, 6:17 a.m.