Epgo_tte: Expected probability to go to phase III for time-to-event...

In Sterniii3/drugdevelopR: Utility-Based Optimal Phase II/III Drug Development Planning

Expected probability to go to phase III for time-to-event outcomes

Description

Expected probability to go to phase III for time-to-event outcomes

Usage

Epgo_tte(HRgo, d2, w, hr1, hr2, id1, id2, fixed)

Arguments

HRgo	threshold value for the go/no-go decision rule
d2	total number of events for phase II; must be even number
w	weight for mixture prior distribution
hr1	first assumed true treatment effect on HR scale for prior distribution
hr2	second assumed true treatment effect on HR scale for prior distribution
id1	amount of information for hr1 in terms of number of events
id2	amount of information for hr2 in terms of number of events
fixed	choose if true treatment effects are fixed or random, if TRUE hr1 is used as fixed effect

Value

The output of the functions Epgo_tte() is the expected probability to go to phase III.

Examples

res <- Epgo_tte(HRgo = 0.8, d2 = 50,  
                                w = 0.3, hr1 = 0.69, hr2 = 0.81, 
                                id1 = 280, id2 = 420, fixed = FALSE)

Sterniii3/drugdevelopR documentation built on Jan. 14, 2025, 7:50 p.m.