optimal_generic: Generic function for optimizing drug development programs

In Sterniii3/drugdevelopR: Utility-Based Optimal Phase II/III Drug Development Planning

Generic function for optimizing drug development programs

Description

Generic function for optimizing drug development programs

Usage

optimal_generic(beta, alpha, c2, c3, c02, c03, K, N, S, b1, b2, b3, num_cl)

Arguments

c2	variable per-patient cost for phase II
c3	variable per-patient cost for phase III
c02	fixed cost for phase II
c03	fixed cost for phase III
K	constraint on the costs of the program, default: Inf, e.g. no constraint
N	constraint on the total expected sample size of the program, default: Inf, e.g. no constraint
S	constraint on the expected probability of a successful program, default: -Inf, e.g. no constraint
b1	expected gain for effect size category "small"
b2	expected gain for effect size category "medium"
b3	expected gain for effect size category "large"
num_cl	number of clusters used for parallel computing, default: 1

Sterniii3/drugdevelopR documentation built on Jan. 26, 2024, 6:17 a.m.