analyzeSignalConcordanceSingle: Patial SeeCiTe analysis of BAF and LRR in candidate CNV...

Description Usage Arguments Value

View source: R/analyzeSignalConcordanceSingle.R

Description

Patial SeeCiTe analysis of BAF and LRR in candidate CNV regions for a single sample

Usage

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analyzeSignalConcordanceSingle(
  input_data,
  cohen_dist = 3,
  sign_correct_baf = 0.01,
  percent_opposite = 20
)

Arguments

input_data

The input data table from readSingle.

cohen_dist

A cutoff on Cohen distance between CNV and flank LRR value distributions. If cohen distance is equal or smaller that this cutoff the distributions are considered not different without further testing. Default is 3.

sign_correct_baf

A cutoff p-value at which one-sided wilcoxon test of the shift of CNV LRR distribution from zero is considered significant. Used as an additional evidence to correct status based on BAF values which is succeptible to errors when signal is noisy. Default is 0.01.

percent_opposite

A cutoff on percentage of probes that have LRR values in direction contradicting the suggested CNV type, eg positive for a del and negative for a dup. Default is 20.

sign_lrr_dist

A cutoff of p-value at which difference between two individual's CNV LRR value distributions is set as significant, using Kernel density based global two-sample comparison test from ks package. Default is 0.01.

Value

A data table with test results (p-values and classifications) as well as various summaries for CNV and flanking regions per individual and CNV


aksenia/SeeCiTe documentation built on Jan. 19, 2021, 12:35 a.m.