link_pwpca_block: link_pwpca_block

In dengchunyu/scPagwas: A pathway-based polygenic integration method for inferring disease-associated individual cells in single cell sequencing data

link_pwpca_block

Description

Link the pca score and expression for each pathway genes for each block Requires rownames that are identitcal to block labels loaded previously.

Usage

link_pwpca_block(
  pa_block,
  pca_cell_df,
  merge_scexpr,
  snp_gene_df,
  rawPathway_list
)

Arguments

pa_block	snp blocks for pathway.
pca_cell_df	pca matrix for cell types.
merge_scexpr	mean expression for merged cell types of single cell data.
snp_gene_df	Data frame of snp mapping to gene.
rawPathway_list	Raw pathway list before filter

Value

pathway block including "x" "y" "snps" "include_in_inference"

dengchunyu/scPagwas documentation built on Nov. 29, 2024, 2:53 p.m.