generate_gwas_params: Generate SNP effects given MAF, h2 and selection

In explodecomputer/simulateGP: Functions for Simulating Genotype-Phenotype Relationships

Generate SNP effects given MAF, h2 and selection

Description

Generate SNP effects given MAF, h2 and selection

Usage

generate_gwas_params(map, h2, S = 0, Pi = 1)

Arguments

map	Data frame containing at least af allele frequency and snp SNP columns. SNPs must be unique, af must be between 0 and 1. Optionally also include the chr, pos, ref, alt columns if using LD-aware simulations
h2	Variance explained by all SNPs
S	Selection coefficient on trait. Default = 0
Pi	Proportion of variants that have an effect - sampled randomly. Default=1

Value

data frame

explodecomputer/simulateGP documentation built on April 3, 2024, 2:38 a.m.