query_budger: Find drugs that maximally affect a selection of genes
In hms-dbmi/drugseqr: GUI to Explore Single-Cell and Bulk RNA-Seq from Fastq to Pathways and Perturbations
query_budger R Documentation
Find drugs that maximally affect a selection of genes
Description
Results are based on the average effect on the query genes. Genes to upregulate are multiplied by -1 so that
strong positive results for these genes contribute towards a more negative average effect. All results are divided
by the absolute of the average minimum effect (after -1 multiplication of genes to upregulate) of the query genes.
This ensures that results will be between -1 and 1 for consistency with correlation values for query_drugs.
Usage
query_budger(query_genes, drug_es)
Arguments
query_genes
Named list of character vectors with 'dn' indicating genes that want to down-regulated and
'up' indicating genes that want to up-regulate.
drug_es
A matrix of differential expression values for drugs.
Value
Named numeric vector where most negative results are predicted to have the strongest desired effect as
indicated by query_genes.
hms-dbmi/drugseqr documentation built on Feb. 15, 2024, 10:38 p.m.
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| query_budger | R Documentation |
Find drugs that maximally affect a selection of genes
Description
Results are based on the average effect on the query genes. Genes to upregulate are multiplied by -1 so that
strong positive results for these genes contribute towards a more negative average effect. All results are divided
by the absolute of the average minimum effect (after -1 multiplication of genes to upregulate) of the query genes.
This ensures that results will be between -1 and 1 for consistency with correlation values for query_drugs.
Usage
query_budger(query_genes, drug_es)
Arguments
query_genes |
Named list of character vectors with |
drug_es |
A matrix of differential expression values for drugs. |
Value
Named numeric vector where most negative results are predicted to have the strongest desired effect as
indicated by query_genes.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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