README.md

In lshen1/drexplorer2: Dose-response Explorer2

drexplorer2

Introduction

The drexplorer2 R package is developed to facilitate the analysis of dose-response data. It can be used to:

• assess the reproducibility of replicates,
• detect outlier data points
• fit different models
• select the best model
• estimate IC (Inhibition Concentration, e.g. IC50) values at different percentiles
• evaluate drug-drug interactions using interaction index
• implement NCI 60 method (estimation of GI50, TGI, LD50 and calculation of AOC_GR, AOC_LD, AUC_GRI)
• implement Hill equation (Estimation of EC50, Emax, Einf, E0 and Hill slope)
• Calculate AUC (Area Under Curve) for all models

A figure summary of its functions can be found from our paper (figure cited from PubMed Central):

Installation

The devtools package is used to install R packages hosted on Github. To install drexplorer2, type the following commands in the R console:

library(devtools)
install_github("lshen1/drexplorer2")

Usage

# load the package
library(drexplorer2)

# GUI for dose-response curve fitting
drexplorerGUI_1()

# GUI for drug-drug interaction
drexplorerGUI_2()

User Manual

A manual is available.

lshen1/drexplorer2 documentation built on June 2, 2020, 9:27 p.m.