fit_median_efect: Fit median-effect model for 2-drug combination with a fixed...

In lshen1/drexplorer2: Dose-response Explorer2

Description

Notice that the median-effect model is a special case of the sigma Emax model; 3 linear models are fitted; fixed ratio thus is required. All 3 linear models are fitted using logit(E) ~ log(d1+d2) using a subset of the data depending on if the data is for durg 1, drug 2 and the mixture

Usage

fit_median_efect(
  d1,
  d2,
  e,
  name1 = "Drug A",
  name2 = "Drug B",
  d2.d1,
  base = exp(1)
)

Arguments

d1	dose for drug 1.
d2	dose for drug 2.
e	corresponding response in the range [0, 1].
name1	drug 1 name.
name2	drug 2 name.
d2.d1	d2/d1, the fixed ratio.
base	base of logarithm; disabled since the dose-response curve estimation also needs transformation.

Value

a list.

lshen1/drexplorer2 documentation built on June 2, 2020, 9:27 p.m.