bootstrap of fitHSA_ray to obtain variation of deltaAUC
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15  | fitHSA_ray_boot(
  d1,
  d2,
  e,
  tol = 0.05,
  strict = TRUE,
  name1 = "Drug A",
  name2 = "Drug B",
  dmin = NULL,
  dmax = NULL,
  islogd = TRUE,
  bootstrapB = 10,
  nrep = 3,
  seed = 100
)
 | 
d1 | 
 drug 1 dose in original scale.  | 
d2 | 
 drug 2 dose in original scale.  | 
e | 
 response at the dose pair.  | 
tol | 
 tolerance in declaring fixed ratio.  | 
strict | 
 whether to stop if not fixed ratio; this is just for visualization; the calculations of synergy is wrong since d12 = d1+d2 is meaningless for variable ratio! At the end, this is a waste of time: it would not make sense and impossible to do this!  | 
name1 | 
 drug 1 name.  | 
name2 | 
 drug 2 name.  | 
dmin | 
 start position to calcualte AUC at projected dose, in original scale, default is minimum projected dose.  | 
dmax | 
 end position to calcualte AUC at projected dose, in original scale, default is maximum projected dose.  | 
islogd | 
 whether to compute AUC at log10 dose; if TRUE, dmin and dmax must also be log10 scale.  | 
bootstrapB | 
 number of boostrap iterations.  | 
nrep | 
 how many replicates are sampled with replacement for each dose combination. nrep=3 will make it much narrower CI band.  | 
seed | 
 random seed. Dafault is set to 100.  | 
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