bootstrap of fitHSA_ray to obtain variation of deltaAUC
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 | fitHSA_ray_boot(
d1,
d2,
e,
tol = 0.05,
strict = TRUE,
name1 = "Drug A",
name2 = "Drug B",
dmin = NULL,
dmax = NULL,
islogd = TRUE,
bootstrapB = 10,
nrep = 3,
seed = 100
)
|
d1 |
drug 1 dose in original scale. |
d2 |
drug 2 dose in original scale. |
e |
response at the dose pair. |
tol |
tolerance in declaring fixed ratio. |
strict |
whether to stop if not fixed ratio; this is just for visualization; the calculations of synergy is wrong since d12 = d1+d2 is meaningless for variable ratio! At the end, this is a waste of time: it would not make sense and impossible to do this! |
name1 |
drug 1 name. |
name2 |
drug 2 name. |
dmin |
start position to calcualte AUC at projected dose, in original scale, default is minimum projected dose. |
dmax |
end position to calcualte AUC at projected dose, in original scale, default is maximum projected dose. |
islogd |
whether to compute AUC at log10 dose; if TRUE, dmin and dmax must also be log10 scale. |
bootstrapB |
number of boostrap iterations. |
nrep |
how many replicates are sampled with replacement for each dose combination. nrep=3 will make it much narrower CI band. |
seed |
random seed. Dafault is set to 100. |
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