fitHSA_ray: Fit HSA and Bliss model given a fixed ratio design with input...

Description Usage Arguments Value

Description

Fit HSA and Bliss model given a fixed ratio design with input (d1, d2, e)

Usage

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fitHSA_ray(
  d1,
  d2,
  e,
  tol = 0.05,
  strict = TRUE,
  name1 = "Drug A",
  name2 = "Drug B",
  dmin = NULL,
  dmax = NULL,
  islogd = TRUE,
  bootstrapB = 0,
  nrep = 3,
  seed = 100
)

Arguments

d1

drug 1 dose in original scale.

d2

drug 2 dose in original scale.

e

response at the dose pair.

tol

tolerance in declaring fixed ratio.

strict

whether to stop if not fixed ratio; this is just for visualization; the calculations of synergy is wrong since d12 = d1+d2 is meaningless for variable ratio! At the end, this is a waste of time: it would not make sense and impossible to do this!

name1

drug 1 name.

name2

drug 2 name.

dmin

start position to calcualte AUC at projected dose, in original scale, default is minimum projected dose.

dmax

end position to calcualte AUC at projected dose, in original scale, default is maximum projected dose.

islogd

whether to compute AUC at log10 dose; if TRUE, dmin and dmax must also be log10 scale.

bootstrapB

number of boostrap iterations.

nrep

how many replicates are sampled with replacement for each dose combination. nrep=3 will make it much narrower CI band.

seed

random seed. Dafault is set to 100.

Value

a list


lshen1/drexplorer2 documentation built on June 2, 2020, 9:27 p.m.