Description Usage Arguments Value
Fit HSA and Bliss model given a fixed ratio design with input (d1, d2, e)
| 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 | fitHSA_ray(
  d1,
  d2,
  e,
  tol = 0.05,
  strict = TRUE,
  name1 = "Drug A",
  name2 = "Drug B",
  dmin = NULL,
  dmax = NULL,
  islogd = TRUE,
  bootstrapB = 0,
  nrep = 3,
  seed = 100
)
 | 
| d1 | drug 1 dose in original scale. | 
| d2 | drug 2 dose in original scale. | 
| e | response at the dose pair. | 
| tol | tolerance in declaring fixed ratio. | 
| strict | whether to stop if not fixed ratio; this is just for visualization; the calculations of synergy is wrong since d12 = d1+d2 is meaningless for variable ratio! At the end, this is a waste of time: it would not make sense and impossible to do this! | 
| name1 | drug 1 name. | 
| name2 | drug 2 name. | 
| dmin | start position to calcualte AUC at projected dose, in original scale, default is minimum projected dose. | 
| dmax | end position to calcualte AUC at projected dose, in original scale, default is maximum projected dose. | 
| islogd | whether to compute AUC at log10 dose; if TRUE, dmin and dmax must also be log10 scale. | 
| bootstrapB | number of boostrap iterations. | 
| nrep | how many replicates are sampled with replacement for each dose combination. nrep=3 will make it much narrower CI band. | 
| seed | random seed. Dafault is set to 100. | 
a list
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