generate_combined_graphs: Combines individual layers to a single graph

In molnet-org/molnet: Predicting Differential Drug Response using Multi-Omics Networks

Description

Individual graphs created by generate_individual_graphs are combined to a single graph per group according to 'inter_layer_connections'. Returns a list of combined graphs along with their annotations.

Usage

generate_combined_graphs(
  graphs,
  annotations,
  inter_layer_connections,
  settings
)

Arguments

graphs	A named list (elements 'group1' and 'group2'). Each element contains a list of iGraph objects (output of generate_individual_graphs).
annotations	A named list (elements 'group1' and 'group2'). Each element contains a list of data frames mapping each node IDs to identifiers (output of generate_individual_graphs).
inter_layer_connections	Named list with specified inter-layer connections. Names are layer names and elements are connections (make_connection).
settings	A named list containing pipeline settings

Value

A named list (elements 'graphs' and 'annotations' and sub-elements '$group1' and '$group2'). Contains the igraph objects of the combined network and their annotations for both groups.

Examples

data(individual_graphs_example)
individual_graphs <- individual_graphs_example
inter_layer_connections <- list(molnet::make_connection(from="mrna",
to="protein", connect_on="gene_name", weight=1))
settings <- molnet::molnet_settings() # defaults
combined_graphs <- molnet::generate_combined_graphs(individual_graphs$graphs,
                                                    individual_graphs$annotations,
                                                    inter_layer_connections,
                                                    settings)

molnet-org/molnet documentation built on Dec. 21, 2021, 8:59 p.m.