fitMLE: Maximum likelihood inference of signature proportions

In mskcc/tempoSig: Maximum Likelihood Fitting of Mutational Catalogs and De Novo Inference of Signatures

Maximum likelihood inference of signature proportions

Description

Maximum likelihood inference of signature proportions

Usage

fitMLE(x, ref, itmax = 1000, tol = 1e-04)

Arguments

x	Vector of observed proportions of mutation contexts
ref	Matrix of reference signature proportions with mutation types in rows and signatures in columns
itmax	Maximum number of iterations
tol	Tolerance of convergence

Value

List of exposure vector p and loglik

mskcc/tempoSig documentation built on Feb. 3, 2023, 8:35 a.m.