powerEstimate: Estimate Power for Signature Detection

In mskcc/tempoSig: Maximum Likelihood Fitting of Mutational Catalogs and De Novo Inference of Signatures

Estimate Power for Signature Detection

Description

Estimate Power for Signature Detection

Usage

powerEstimate(
  proportion,
  reference = "v2",
  use.model = TRUE,
  nsamp = 100,
  Mcoeff = NULL,
  afit = NULL,
  bfit = NULL,
  Msamp = NULL,
  verbose = TRUE,
  alpha = 0.05,
  Pmin = 0.8,
  ...
)

Arguments

proportion	Vector of signature proportions
reference	Reference signature version; currently only supports c('SA').
use.model	Use parametrized model. If FALSE, multinomial model will be simulated.
nsamp	No. of samples to use for simulation
Msamp	Vector mutation loads to sample
verbose	Print messages during sampling
alpha	False positive rate
Pmin	Lower bound for power
cut	Remove signatures with proportions below cut.

mskcc/tempoSig documentation built on Feb. 3, 2023, 8:35 a.m.