Description Usage Arguments Value
analytically compute the variance of a projection given a standard error of beta for a given trait
compute_seb_proj_var
1 2 3 4 5 6 7 8 9  | compute_seb_proj_var(
  gwas.DT,
  shrink.DT,
  man.DT,
  w.DT,
  ref_gt_dir,
  method = "shrinkage",
  quiet = FALSE
)
 | 
gwas.DT | 
 a data.table - variants and summary statistics  | 
shrink.DT | 
 a data.table - as returned by   | 
man.DT | 
 a data.table - snp manifest file that maps snps to ld.block  | 
w.DT | 
 a data.table - a data table of weights/rotations from a basis first column is 'pid' and subsequent columns for each principal component.  | 
ref_gt_dir | 
 scalar - path to a dir of R objects named CHR_1kg.RData containing reference GT in snpMatrix format  | 
method | 
 scalar - shrinkage method to use (default shrinkage) but also valid is none  | 
quiet | 
 a scalar - boolean whether to show progress messages  | 
a scalar of variances for each principal component
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