lor_f: This function samples from the posterior distribution of a...

In ollyburren/cupcake: PCA for GWAS

Description

This function samples from the posterior distribution of a given control allele frequency, for different genotype configurations lor_f sample from log(or) posterior distribution given an allele frequency.

Usage

lor_f(f0, n, target.or, target.prob, n.steps)

Arguments

f0	a scalar - allele frequency in cases to simulate
n	a scalar - number of individuals sampled
target.or	a scalar - an odds ratio threshold to compute P(sim.or > target.or)
target.prob	a scalar - a probability that a sampled variant will exceed target.or
n.steps	an integer - length of search grid to employ - larger gives a more accurate integral estimate

Value

a list object

1. 00 - mean lor for reference hom

2. 01 - mean lor for het

3. 11 - mean lor for alternative hom

4. quant00 - quantiles for posterior distribution of allele frequency in cases for ref hom

5. quant01 - quantiles for posterior distribution of allele frequency in cases for het

6. quant11 - quantiles for posterior distribution of allele frequency in cases for alt hom

ollyburren/cupcake documentation built on July 30, 2020, 9:58 a.m.