CI: Print information regarding absorbance data object.

Description Usage Arguments Value Note Author(s) References See Also Examples

View source: R/dataflow.R

Description

Prints information regarding drugs and cell lines to be analysed

Usage

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CI(A.data, ...)

## S3 method for class 'summary.DRdata'
CI(A.data, ..., model = "G",
   types =  c("GI50", "TGI", "LC50", "AUC"),
   conf  = c(2.5, 97.5),
   time  = "48",
   dose.scale  = "mol/l",
   dose.logfun = "log10")

Arguments

A.data

A.data object created by the function summary.DRdata.

...

Further arguments passed to other methods.

model

character, the dose response model to get the summary satistices from.

types

vector of characters with the names of the summary statistics.

conf

Numeric vector of legth two with the limits of the confidence interval.

time

The time used for the summary statistic LC50 for the G-model. E.g. setting t=48 indicates that the LC50 for the G model is actually the LC48.

dose.scale

Character indicating the scale used for concentrations when estimating the isotonic regression and the summary statistcs. The unit is written as e.g. ug/ml to indicate micro grams per milli litre and defaults to mol/l. The unit is written as ug/ml The current implementations for multiples are:

Name deca hecto kilo mega giga tera peta exa zetta yotta
Prefix da h k M G T P E Z Y
Factor 10^0 10^1 10^2 10^3 10^6 10^9 10^12 10^15 10^18 10^21 10^24

The current implementations for fractions are:

Name deci centi milli micro nano pico femto atto zepto yocto
Prefix d c m u n p f a z y
Factor 10^-1 10^-2 10^-3 10^-6 10^-9 10^-12 10^-15 10^-18 10^-21 10^-24
dose.logfun

Character indicating if the concentrations should be log transformed. The possible inputs are nolog for non log transformation, log10, log2, log for log transforming with base 10, 2, and e, respectively.

Value

Confidence intervals for the chosen summary statistics and drugs. T0 corresponds to the estimated doubling time.

Note

When the dose response models have been estimated it is possible to make various plots of the data. The estimated summary statistics are obtainable using the function CI. See the examples for further usage of the A.data object.

Author(s)

The function was written at department of haematology, Aalborg University Hospital and maintained by Steffen Falgreen.

References

Steffen Falgreen et al. Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition (2013)

See Also

pdfCI,tableCI,DRdataBoxplot,plot.DRdata,plot.growthModel,plotGrid

Examples

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require(DoseR)
## load Dose Response data
data(A.data)
CI(A.data)

oncoclass/DoseR documentation built on Nov. 23, 2017, 4:12 a.m.