differentialMethylation: Differential methylation analysis.

Description Usage Arguments Value Author(s)

Description

Analysis of differentially methylated positions (DMPs) and detection of differentially methylated regions (DMRs).

Usage

1
2
differentialMethylation(M, targets, array.annot.gr, betas = ilogit2(M),
  interest.vars = NULL, outdir = getwd(), ncores = 1, invisible = T)

Arguments

M

matrix with M values

targets

data frame with sample annotation to be used to run limma

array.annot.gr

GRanges object with array annotation

betas

matrix with Beta values

interest.vars

character vector with variables of interest, excluding the confounding factors

outdir

path to save results

ncores

integer. Number of cores to use to parallellize the DMR analysis

invisible

a boolean to determine if the output of 'missMethyl::gometh' is returned

Value

limma::eBayes

Author(s)

Xavier Pastor x.pastorhostench@dkfz.de


xpastor/skima documentation built on May 16, 2019, 3:25 p.m.