Description Usage Arguments Value Author(s) Examples
Runs the SKIMA workflow.
1 2 3 4 5 6 7 8 9 10 11 | run(idat_dir = Sys.getenv("IDAT_DIR"),
sample.annotation = Sys.getenv("SAMPLE_ANNOTATION"),
blacklist = Sys.getenv("BLACKLIST"), outdir = Sys.getenv("OUTDIR"),
runCNV = as.logical(Sys.getenv("RUN_CNV")),
diffMeth = as.logical(Sys.getenv("RUN_DIFFERENTIAL_METHYLATION")),
removeSNPs = as.logical(Sys.getenv("REMOVE_SNPS")),
population = Sys.getenv("POPULATION"),
usePredictedSex = as.logical(Sys.getenv("USE_PREDICTED_SEX")),
batch.vars = Sys.getenv("BATCH_VARS"),
seed = as.integer(Sys.getenv("SEED")),
ncores = as.integer(Sys.getenv("NCORES")))
|
idat_dir |
character. Path to the directory with the idat files. |
sample.annotation |
character. Path to the sample sheet with all the annotation about the samples. Must have a column named 'Sample_Name' with unique sample identifiers, a column named 'Sentrix_ID' with the array identifier and a column named 'Sentrix_Position' with the position in the array where the sample was hybridized. |
blacklist |
character. Path to a file with probes to be flagged or removed from the analysis. |
outdir |
character. Directory where all the results will be writen. |
runCNV |
boolean. Should the CNV analysis be run? |
diffMeth |
boolean. Should the differential methylation analsysis be run? |
removeSNPs |
boolean. Should polymorphic probes with an allellic frequency higher than 1/nrow(sample.annotation) in the population given in 'population' be removed? |
population |
character. A string defining the population where to compare allellic frequencies. One of: NULL, ”, 'AFR', 'AMR', 'ASN', 'EUR', 'SAS', 'EAS'. NULL and ” will compare to global allellic frequencies. |
usePredictedSex |
boolean. Should the predicted sex be included in the analysis, and used as confounding variable? |
batch.vars |
character. String with a list of columns from |
seed |
integer. Seed to avoid randomness and make the analysis reproducible. |
ncores |
integer. Number of cores to use for the multithreaded processes. |
None
Xavier Pastor x.pastorhostench@dkfz.de
1 | run()
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