Description Details Author(s) References

This package provides functions for the integrated analysis of biological networks and the detection of functional modules. Different datasets can be integrated into the network by assigning p-values derived from statistical tests to the nodes of the network. E.g. p-values obtained from the differential expression of genes from an Affymetrix array are assigned to the nodes of an protein-protein interaction network. By fitting a beta-uniform mixture model and calculating scores from the p-values, overall scores of network regions can be calculated and an integer linear programming algorithm identifies the maximum scoring subnetwork.

Package: | BioNet |

Type: | Package |

Version: | 1.29.1 |

Date: | 2015-09-11 |

License: | GPL (>=2) |

LazyLoad: | yes |

Marcus Dittrich, Daniela Beisser

Maintainer: Marcus Dittrich <[email protected]>

M. T. Dittrich, G. W. Klau, A. Rosenwald, T. Dandekar and T. Mueller (2008) Identifying functional modules in protein-protein interaction networks: an integrated exact approach. *(ISMB2008) Bioinformatics* 24: 13. i223-i231 Jul.

D. Beisser, G. W. Klau, T. Dandekar, T. Mueller and M. Dittrich (2010) BioNet: an R-package for the Functional Analysis of Biological Networks. *Bioinformatics* 26:08. 1129-1130 Apr.

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