This package provides functions for the integrated analysis of protein-protein interaction networks and the detection of functional modules. Different datasets can be integrated into the network by assigning p-values of statistical tests to the nodes of the network. E.g. p-values obtained from the differential expression of the genes from an Affymetrix array are assigned to the nodes of the network. By fitting a beta-uniform mixture model and calculating scores from the p-values, overall scores of network regions can be calculated and an integer linear programming algorithm identifies the maximum scoring subnetwork.
|Author||Marcus Dittrich and Daniela Beisser|
|Bioconductor views||DataImport DifferentialExpression GeneExpression GraphAndNetwork Microarray Network NetworkEnrichment|
|Maintainer||Marcus Dittrich <[email protected]>|
|License||GPL (>= 2)|
|Package repository||View on Bioconductor|
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