This package provides functions for the integrated analysis of proteinprotein interaction networks and the detection of functional modules. Different datasets can be integrated into the network by assigning pvalues of statistical tests to the nodes of the network. E.g. pvalues obtained from the differential expression of the genes from an Affymetrix array are assigned to the nodes of the network. By fitting a betauniform mixture model and calculating scores from the pvalues, overall scores of network regions can be calculated and an integer linear programming algorithm identifies the maximum scoring subnetwork.
Package details 


Author  Marcus Dittrich and Daniela Beisser 
Bioconductor views  DataImport DifferentialExpression GeneExpression GraphAndNetwork Microarray Network NetworkEnrichment 
Maintainer  Marcus Dittrich <marcus.dittrich@biozentrum.uniwuerzburg.de> 
License  GPL (>= 2) 
Version  1.47.0 
URL  http://bionet.bioapps.biozentrum.uniwuerzburg.de/ 
Package repository  View on Bioconductor 
Installation 
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