COMPASS: Combinatorial Polyfunctionality Analysis of Single Cells

COMPASS is a statistical framework that enables unbiased analysis of antigen-specific T-cell subsets. COMPASS uses a Bayesian hierarchical framework to model all observed cell-subsets and select the most likely to be antigen-specific while regularizing the small cell counts that often arise in multi-parameter space. The model provides a posterior probability of specificity for each cell subset and each sample, which can be used to profile a subject's immune response to external stimuli such as infection or vaccination.

Package details

AuthorLynn Lin, Kevin Ushey, Greg Finak, Ravio Kolde (pheatmap)
Bioconductor views FlowCytometry ImmunoOncology
MaintainerGreg Finak <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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COMPASS documentation built on Nov. 8, 2020, 8:05 p.m.