Description Usage Arguments Details Value Examples
View source: R/COMPASSContainer.R
This function generates the data container suitable for use with
COMPASS
.
1 2 3 4 5 6 7 8 | COMPASSContainer(
data,
counts,
meta,
individual_id,
sample_id,
countFilterThreshold = 0
)
|
data |
A list of matrices. Each matrix |
counts |
A named integer vector of the cell counts(of the parent population) for each
sample in |
meta |
A |
individual_id |
The name of the vector in |
sample_id |
The name of the vector in |
countFilterThreshold |
Numeric; if the number of parent cells is less than this threshold, we remove that file. Default is 0, which means filter is disabled. |
The names
attributes for the data
and counts
objects passed should match.
A COMPASSContainer
returns a list made up of the same
components as input the model, but checks and sanitizes the supplied data
to ensure that it conforms to the expectations outlied above.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 | set.seed(123)
n <- 10 ## number of samples
k <- 3 ## number of markers
## generate some sample data
sid_vec <- paste0("sid_", 1:n) ## sample ids; unique names used to denote samples
iid_vec <- rep_len( paste0("iid_", 1:(n/2) ), n ) ## individual ids
## generate n matrices of 'cell intensities'
data <- replicate(n, {
nrow <- round(runif(1) * 1E2 + 1000)
ncol <- k
vals <- rexp( nrow * ncol, runif(1, 1E-5, 1E-3) )
vals[ vals < 2000 ] <- 0
output <- matrix(vals, nrow, ncol)
output <- output[ apply(output, 1, sum) > 0, ]
colnames(output) <- paste0("M", 1:k)
return(output)
})
names(data) <- sid_vec
## make a sample metadata data.frame
meta <- data.frame(
sid=sid_vec,
iid=iid_vec,
trt=rep( c("Control", "Treatment"), each=5 )
)
## generate an example total counts
## recall that cells not expressing any marker are not included
## in the 'data' matrices
counts <- sapply(data, nrow) + round( rnorm(n, 1E3, 1E2) )
counts <- setNames( as.integer(counts), names(counts) )
## insert everything into a COMPASSContainer
CC <- COMPASSContainer(data, counts, meta, "iid", "sid")
|
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