This package implements gene and gene-set level analysis methods for somatic mutation studies of cancer. The gene-level methods distinguish between driver genes (which play an active role in tumorigenesis) and passenger genes (which are mutated in tumor samples, but have no role in tumorigenesis) and incorporate a two-stage study design. The gene-set methods implement a patient-oriented approach, which calculates gene-set scores for each sample, then combines them across samples; a gene-oriented approach which uses the Wilcoxon test is also provided for comparison.
|Author||Giovanni Parmigiani, Simina M. Boca|
|Bioconductor views||Genetics Software|
|Maintainer||Simina M. Boca <[email protected]>|
|License||GPL (>= 2) + file LICENSE|
|Package repository||View on Bioconductor|
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