createMotifRelevantTfs: Get family of transcription factors

In ELMER: Inferring Regulatory Element Landscapes and Transcription Factor Networks Using Cancer Methylomes

Description

This will output a list each TF motif and TFs that binding the motis. Multiple TFs may recognize a same motif such as TF family. The association between each motif famil and transcription factor was created using the (HOCOMOCO)[http://hocomoco.autosome.ru/human/mono] which TF structural families was created according to TFClass [@wingender2014tfclass] This data is stored as a list whose elements are motifs and contents for each element are TFs which recognize the same motif that is the name of the element. This data is used in function get.TFs in ELMER to identify the real regulator TF whose motif is enriched in a given set of probes and expression associate with average DNA methylation of these motif sites.

Usage

createMotifRelevantTfs(classification = "family")

Arguments

classification

Select if we will use Family classification or sub-family

Value

A list of TFs and its family members

ELMER documentation built on Nov. 8, 2020, 4:59 p.m.