getDiggitEmpiricalQvalues: Compute the empirical q-values of each genomic-event/VIPER...

In MOMA: Multi Omic Master Regulator Analysis

Description

Use against the background distribution of associations with a given set of 'null' VIPER genes (i.e. low activity TFs)

Usage

getDiggitEmpiricalQvalues(vipermat, nes, null.TFs, alternative = "both")

Arguments

vipermat	viper inferences matrix, samples are columns, rows are TF entrez gene IDs
nes	scores for each mutation (rows) against each TF (columns)
null.TFs	low-importance TFs used to calculate null distributions
alternative	Alternative defaults to 'both' : significant p-values can come from both sides of the null distribution

Value

A named list of qvalues for each TF/cMR protein. Each entry contains a vector of q-values for all associated events; names are gene ids

MOMA documentation built on Nov. 8, 2020, 6:01 p.m.