PMID17290060: An integrated genomic-based approach to individualized...
In MetaGxOvarian: Transcriptomic Ovarian Cancer Datasets
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Description
The purpose of this study was to develop an integrated genomic-based approach to personalized treatment of patients with advanced-stage ovarian cancer. We have used gene expression profiles to identify patients likely to be resistant to primary platinum-based chemotherapy and also to identify alternate targeted therapeutic options for patients with de novo platinum-resistant disease.A gene expression model that predicts response to platinum-based therapy was developed using a training set of 83 advanced-stage serous ovarian cancers and tested on a 36-sample external validation set. In parallel, expression signatures that define the status of oncogenic signaling pathways were evaluated in 119 primary ovarian cancers and 12 ovarian cancer cell lines. In an effort to increase chemotherapy sensitivity, pathways shown to be activated in platinum-resistant cancers were subject to targeted therapy in ovarian cancer cell lines.Gene expression profiles identified patients with ovarian cancer likely to be resistant to primary platinum-based chemotherapy with greater than 80% accuracy. In patients with platinum-resistant disease, we identified expression signatures consistent with activation of Src and Rb/E2F pathways, components of which were successfully targeted to increase response in ovarian cancer cell lines.We have defined a strategy for treatment of patients with advanced-stage ovarian cancer that uses therapeutic stratification based on predictions of response to chemotherapy, coupled with prediction of oncogenic pathway deregulation, as a method to direct the use of targeted agents.
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experimentData(eset):
Experiment data
Experimenter name: Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsburg GS, Potti A, West M, Nevins JR, Lancaster JM.An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. J Clin Oncol. 2007 Feb 10; 25(5):517-25.
Laboratory: Dressman, Lancaster 2007
Contact information:
Title: An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.
URL:
PMIDs: 17290060
Abstract: A 223 word abstract is available. Use 'abstract' method.
Information is available on: preprocessing
notes:
platform_title:
[HG-U133A] Affymetrix Human Genome U133A Array
platform_shorttitle:
Affymetrix HG-U133A
platform_summary:
hgu133a
platform_manufacturer:
Affymetrix
platform_distribution:
commercial
platform_accession:
GPL96
warnings:
This paper has been retracted.
version:
2015-09-22 20:19:16
featureData(eset):
An object of class 'AnnotatedDataFrame'
featureNames: 1007_s_at 1053_at ... AFFX-HUMISGF3A/M97935_MB_at
(20967 total)
varLabels: probeset gene EntrezGene.ID best_probe
varMetadata: labelDescription
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assayData: 20967 features, 117 samples
Platform type:
Overall survival time-to-event summary (in years):
Call: survfit(formula = Surv(time, cens) ~ -1)
n events median 0.95LCL 0.95UCL
117.00 67.00 5.26 2.79 7.48
---------------------------
Available sample meta-data:
---------------------------
alt_sample_name:
1024 1447 1451 1504 1526 1552 1578 1590 1615 1623
1 1 1 1 1 1 1 1 1 1
1665 1674 1675 1774 1784 1834 1846 1877 1913 1929
1 1 1 1 1 1 1 1 1 1
2046 2063 2064 2075 2198 2204 2324 2419 2422 2424
1 1 1 1 1 1 1 1 1 1
2465 2476 2479 2505 2542 2573 2673 2739 2802 2849
1 1 1 1 1 1 1 1 1 1
2895 2967 2981 2999 3018 3090 3102 3107 3142 860
1 1 1 1 1 1 1 1 1 1
872 922 D1805 D1837 D1859 D2098 D2208 D2332 D2342 D2358
1 1 1 1 1 1 1 1 1 1
D2421 D2432 D2433 D2480 D2557 D2559 D2560 D2572 D2575 D2576
1 1 1 1 1 1 1 1 1 1
D2581 D2603 D2611 D2629 D2640 D2648 D2668 D2689 D2691 D2700
1 1 1 1 1 1 1 1 1 1
D2726 D2727 D2733 D2738 D2749 D2776 D2792 M1054 M1055 M120
1 1 1 1 1 1 1 1 1 1
M1241 M1390 M1503 M1572 M17 M1891 M2070 M2097 M2184 (Other)
1 1 1 1 1 1 1 1 1 18
sample_type:
tumor
117
histological_type:
ser
117
primarysite:
ov
117
summarygrade:
high low NA's
57 57 3
summarystage:
early late NA's
1 115 1
tumorstage:
2 3 4 NA's
1 98 17 1
grade:
1 2 3 4 NA's
4 53 56 1 3
days_to_death:
Min. 1st Qu. Median Mean 3rd Qu. Max.
30 510 1020 1496 2220 5550
vital_status:
deceased living
67 50
primary_therapy_outcome_success:
completeresponse progressivedisease
85 32
debulking:
optimal suboptimal
63 54
batch:
2002-09-20 2002-10-23 2002-11-12 2002-12-16 2002-12-21 2003-01-03 2003-05-30
10 8 9 1 3 11 10
2004-03-09 2004-03-16 2004-04-20 2004-05-18 2004-05-21 2004-05-27 2004-06-22
16 6 5 15 7 7 1
2004-06-23
8
uncurated_author_metadata:
OVC.TumorID: 1024///Survival: 13///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 3///Debulk: S///CA125.POST: 12///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1447///Survival: 75///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 8.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1451///Survival: 132///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 16///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1504///Survival: 108///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 4///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1526///Survival: 74///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 5.1///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1552///Survival: 33///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 9.9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1578///Survival: 33///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: O///CA125.POST: 8.7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1590///Survival: 148///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1615///Survival: 13///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 875///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1623///Survival: 147///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 1///Debulk: O///CA125.POST: 4///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1665///Survival: 15///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 500///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1674///Survival: 18///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 15///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1675///Survival: 34///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 14.4///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1774///Survival: 22///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 33.3///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1784///Survival: 78///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 32///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1834///Survival: 118///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 17///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1846///Survival: 142///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1877///Survival: 119///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1913///Survival: 32///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: <20///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1929///Survival: 134///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 4///Debulk: S///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2046///Survival: 127///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2063///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 26.8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2064///Survival: 27///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: ELEVATED///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2075///Survival: 87///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2198///Survival: 91///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2204///Survival: 118///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2324///Survival: 98///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2419///Survival: 107///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 10///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2422///Survival: 20///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2424///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 1117///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2465///Survival: 17///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 4928///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2476///Survival: 86///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 56.1///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2479///Survival: 95///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 16.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2505///Survival: 95///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 12///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2542///Survival: 36///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2573///Survival: 7///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 641.3///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2673///Survival: 74///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 11.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2739///Survival: 67///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 10///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2802///Survival: 24///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 402///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2849///Survival: 23///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 37.6///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2895///Survival: 9///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 41.6///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2967///Survival: 22///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 26///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2981///Survival: 6///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 30.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2999///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 2291///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3018///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 6.2///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3090///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: O///CA125.POST: 10.8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3102///Survival: 10///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: ?///Debulk: S///CA125.POST: 127.3///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3107///Survival: 31///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 11.2///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3142///Survival: 18///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 52///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 860///Survival: 17///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 3///Debulk: O///CA125.POST: 133///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 872///Survival: 185///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 3.1///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 922///Survival: 183///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D1805///Survival: 9///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: S///CA125.POST: 331///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D1837///Survival: 83///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 11.3///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D1859///Survival: 110///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 15///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2098///Survival: 42///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: NA///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2208///Survival: 2///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 3///Debulk: S///CA125.POST: 808.6///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2332///Survival: 27///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 11///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2342///Survival: 20///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 473///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2358///Survival: 9///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: O///CA125.POST: 29///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2421///Survival: 12///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 35///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2432///Survival: 34///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2433///Survival: 49///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 12.7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2480///Survival: 34///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 29.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2557///Survival: 62///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 1920///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2559///Survival: 5///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 3///Debulk: O///CA125.POST: 9.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2560///Survival: 91///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 10.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2572///Survival: 37///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 24///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2575///Survival: 33///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: O///CA125.POST: 13.7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2576///Survival: 17///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 43.1///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2581///Survival: 63///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 1///Debulk: O///CA125.POST: 48///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2603///Survival: 42///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 15.2///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2611///Survival: 2///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 134///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2629///Survival: 36///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 2///Debulk: S///CA125.POST: 56///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2640///Survival: 1///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 158.3///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2648///Survival: 35///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 58.7///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2668///Survival: 40///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: ///Debulk: S///CA125.POST: ///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2689///Survival: 45///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 13.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2691///Survival: 63///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 16.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2700///Survival: 74///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 13.9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2726///Survival: 71///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 6.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2727///Survival: 53///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 44///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2733///Survival: 55///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 12.1///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2738///Survival: 68///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 37.9///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2749///Survival: 24///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 16.3///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2776///Survival: 10///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 41.2///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2792///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 32.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1054///Survival: 101///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: UNK///Debulk: Optimal///CA125.POST: 46///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1055///Survival: 13///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3 ///Debulk: Optimal///CA125.POST: UNK///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M120///Survival: 35///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3 ///Debulk: Optimal///CA125.POST: 2///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1241///Survival: 95///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 3 ///Debulk: Suboptimal///CA125.POST: 10///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1390///Survival: 46///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 3///Debulk: O///CA125.POST: UNK///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1503///Survival: 53///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2/3///Debulk: Optimal///CA125.POST: 19///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1572///Survival: 22///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3 ///Debulk: Optimal///CA125.POST: 49///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M17///Survival: 17///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 2 ///Debulk: Suboptimal///CA125.POST: 4700///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1891///Survival: 12///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 1 ///Debulk: Suboptimal (10/3/97)///CA125.POST: 17///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M2070///Survival: 65///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3 ///Debulk: Suboptimal///CA125.POST: 22///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M2097///Survival: 58///X0...alive...1...dead: 0///Assigned.Stage: 2///GRADE: 2/3///Debulk: Optimal///CA125.POST: ///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M2184///Survival: 34///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3 ///Debulk: Optimal///CA125.POST: 10///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
(Other)
18
Value
An expression set
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Description Format Details Value
Description
The purpose of this study was to develop an integrated genomic-based approach to personalized treatment of patients with advanced-stage ovarian cancer. We have used gene expression profiles to identify patients likely to be resistant to primary platinum-based chemotherapy and also to identify alternate targeted therapeutic options for patients with de novo platinum-resistant disease.A gene expression model that predicts response to platinum-based therapy was developed using a training set of 83 advanced-stage serous ovarian cancers and tested on a 36-sample external validation set. In parallel, expression signatures that define the status of oncogenic signaling pathways were evaluated in 119 primary ovarian cancers and 12 ovarian cancer cell lines. In an effort to increase chemotherapy sensitivity, pathways shown to be activated in platinum-resistant cancers were subject to targeted therapy in ovarian cancer cell lines.Gene expression profiles identified patients with ovarian cancer likely to be resistant to primary platinum-based chemotherapy with greater than 80% accuracy. In patients with platinum-resistant disease, we identified expression signatures consistent with activation of Src and Rb/E2F pathways, components of which were successfully targeted to increase response in ovarian cancer cell lines.We have defined a strategy for treatment of patients with advanced-stage ovarian cancer that uses therapeutic stratification based on predictions of response to chemotherapy, coupled with prediction of oncogenic pathway deregulation, as a method to direct the use of targeted agents.
Format
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 | experimentData(eset):
Experiment data
Experimenter name: Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsburg GS, Potti A, West M, Nevins JR, Lancaster JM.An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. J Clin Oncol. 2007 Feb 10; 25(5):517-25.
Laboratory: Dressman, Lancaster 2007
Contact information:
Title: An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.
URL:
PMIDs: 17290060
Abstract: A 223 word abstract is available. Use 'abstract' method.
Information is available on: preprocessing
notes:
platform_title:
[HG-U133A] Affymetrix Human Genome U133A Array
platform_shorttitle:
Affymetrix HG-U133A
platform_summary:
hgu133a
platform_manufacturer:
Affymetrix
platform_distribution:
commercial
platform_accession:
GPL96
warnings:
This paper has been retracted.
version:
2015-09-22 20:19:16
featureData(eset):
An object of class 'AnnotatedDataFrame'
featureNames: 1007_s_at 1053_at ... AFFX-HUMISGF3A/M97935_MB_at
(20967 total)
varLabels: probeset gene EntrezGene.ID best_probe
varMetadata: labelDescription
|
Details
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 | assayData: 20967 features, 117 samples
Platform type:
Overall survival time-to-event summary (in years):
Call: survfit(formula = Surv(time, cens) ~ -1)
n events median 0.95LCL 0.95UCL
117.00 67.00 5.26 2.79 7.48
---------------------------
Available sample meta-data:
---------------------------
alt_sample_name:
1024 1447 1451 1504 1526 1552 1578 1590 1615 1623
1 1 1 1 1 1 1 1 1 1
1665 1674 1675 1774 1784 1834 1846 1877 1913 1929
1 1 1 1 1 1 1 1 1 1
2046 2063 2064 2075 2198 2204 2324 2419 2422 2424
1 1 1 1 1 1 1 1 1 1
2465 2476 2479 2505 2542 2573 2673 2739 2802 2849
1 1 1 1 1 1 1 1 1 1
2895 2967 2981 2999 3018 3090 3102 3107 3142 860
1 1 1 1 1 1 1 1 1 1
872 922 D1805 D1837 D1859 D2098 D2208 D2332 D2342 D2358
1 1 1 1 1 1 1 1 1 1
D2421 D2432 D2433 D2480 D2557 D2559 D2560 D2572 D2575 D2576
1 1 1 1 1 1 1 1 1 1
D2581 D2603 D2611 D2629 D2640 D2648 D2668 D2689 D2691 D2700
1 1 1 1 1 1 1 1 1 1
D2726 D2727 D2733 D2738 D2749 D2776 D2792 M1054 M1055 M120
1 1 1 1 1 1 1 1 1 1
M1241 M1390 M1503 M1572 M17 M1891 M2070 M2097 M2184 (Other)
1 1 1 1 1 1 1 1 1 18
sample_type:
tumor
117
histological_type:
ser
117
primarysite:
ov
117
summarygrade:
high low NA's
57 57 3
summarystage:
early late NA's
1 115 1
tumorstage:
2 3 4 NA's
1 98 17 1
grade:
1 2 3 4 NA's
4 53 56 1 3
days_to_death:
Min. 1st Qu. Median Mean 3rd Qu. Max.
30 510 1020 1496 2220 5550
vital_status:
deceased living
67 50
primary_therapy_outcome_success:
completeresponse progressivedisease
85 32
debulking:
optimal suboptimal
63 54
batch:
2002-09-20 2002-10-23 2002-11-12 2002-12-16 2002-12-21 2003-01-03 2003-05-30
10 8 9 1 3 11 10
2004-03-09 2004-03-16 2004-04-20 2004-05-18 2004-05-21 2004-05-27 2004-06-22
16 6 5 15 7 7 1
2004-06-23
8
uncurated_author_metadata:
OVC.TumorID: 1024///Survival: 13///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 3///Debulk: S///CA125.POST: 12///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1447///Survival: 75///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 8.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1451///Survival: 132///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 16///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1504///Survival: 108///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 4///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1526///Survival: 74///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 5.1///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1552///Survival: 33///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 9.9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1578///Survival: 33///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: O///CA125.POST: 8.7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1590///Survival: 148///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1615///Survival: 13///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 875///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1623///Survival: 147///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 1///Debulk: O///CA125.POST: 4///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1665///Survival: 15///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 500///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1674///Survival: 18///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 15///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1675///Survival: 34///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 14.4///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1774///Survival: 22///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 33.3///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1784///Survival: 78///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 32///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1834///Survival: 118///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 17///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1846///Survival: 142///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1877///Survival: 119///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1913///Survival: 32///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: <20///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 1929///Survival: 134///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 4///Debulk: S///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2046///Survival: 127///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2063///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 26.8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2064///Survival: 27///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: ELEVATED///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2075///Survival: 87///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2198///Survival: 91///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2204///Survival: 118///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2324///Survival: 98///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2419///Survival: 107///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 10///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2422///Survival: 20///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2424///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 1117///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2465///Survival: 17///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 4928///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2476///Survival: 86///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 56.1///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2479///Survival: 95///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 16.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2505///Survival: 95///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 12///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2542///Survival: 36///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2573///Survival: 7///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 641.3///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2673///Survival: 74///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 11.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2739///Survival: 67///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 10///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2802///Survival: 24///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 402///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2849///Survival: 23///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 37.6///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2895///Survival: 9///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 41.6///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2967///Survival: 22///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 26///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2981///Survival: 6///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 30.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 2999///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 2291///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3018///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 6.2///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3090///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: O///CA125.POST: 10.8///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3102///Survival: 10///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: ?///Debulk: S///CA125.POST: 127.3///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3107///Survival: 31///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 11.2///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 3142///Survival: 18///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 52///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 860///Survival: 17///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 3///Debulk: O///CA125.POST: 133///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 872///Survival: 185///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 3.1///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: 922///Survival: 183///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D1805///Survival: 9///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: S///CA125.POST: 331///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D1837///Survival: 83///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 11.3///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D1859///Survival: 110///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 15///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2098///Survival: 42///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: NA///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2208///Survival: 2///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 3///Debulk: S///CA125.POST: 808.6///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2332///Survival: 27///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 11///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2342///Survival: 20///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 473///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2358///Survival: 9///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: O///CA125.POST: 29///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2421///Survival: 12///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 35///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2432///Survival: 34///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2433///Survival: 49///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 12.7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2480///Survival: 34///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 29.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2557///Survival: 62///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 1920///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2559///Survival: 5///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 3///Debulk: O///CA125.POST: 9.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2560///Survival: 91///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 10.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2572///Survival: 37///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 24///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2575///Survival: 33///X0...alive...1...dead: 1///Assigned.Stage: 4///GRADE: 2///Debulk: O///CA125.POST: 13.7///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2576///Survival: 17///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 43.1///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2581///Survival: 63///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 1///Debulk: O///CA125.POST: 48///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2603///Survival: 42///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: O///CA125.POST: 15.2///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2611///Survival: 2///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 134///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2629///Survival: 36///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 2///Debulk: S///CA125.POST: 56///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2640///Survival: 1///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 158.3///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2648///Survival: 35///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 58.7///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2668///Survival: 40///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: ///Debulk: S///CA125.POST: ///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2689///Survival: 45///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 13.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2691///Survival: 63///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 16.5///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2700///Survival: 74///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 13.9///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2726///Survival: 71///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: S///CA125.POST: 6.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2727///Survival: 53///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 44///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2733///Survival: 55///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 12.1///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2738///Survival: 68///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 37.9///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2749///Survival: 24///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2///Debulk: O///CA125.POST: 16.3///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2776///Survival: 10///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 41.2///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: D2792///Survival: 16///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3///Debulk: S///CA125.POST: 32.6///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1054///Survival: 101///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: UNK///Debulk: Optimal///CA125.POST: 46///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1055///Survival: 13///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3 ///Debulk: Optimal///CA125.POST: UNK///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M120///Survival: 35///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3 ///Debulk: Optimal///CA125.POST: 2///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1241///Survival: 95///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 3 ///Debulk: Suboptimal///CA125.POST: 10///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1390///Survival: 46///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 3///Debulk: O///CA125.POST: UNK///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1503///Survival: 53///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 2/3///Debulk: Optimal///CA125.POST: 19///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1572///Survival: 22///X0...alive...1...dead: 1///Assigned.Stage: 3///GRADE: 3 ///Debulk: Optimal///CA125.POST: 49///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M17///Survival: 17///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 2 ///Debulk: Suboptimal///CA125.POST: 4700///response.0.NR..1.CR.: 0///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M1891///Survival: 12///X0...alive...1...dead: 0///Assigned.Stage: 4///GRADE: 1 ///Debulk: Suboptimal (10/3/97)///CA125.POST: 17///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M2070///Survival: 65///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3 ///Debulk: Suboptimal///CA125.POST: 22///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M2097///Survival: 58///X0...alive...1...dead: 0///Assigned.Stage: 2///GRADE: 2/3///Debulk: Optimal///CA125.POST: ///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
OVC.TumorID: M2184///Survival: 34///X0...alive...1...dead: 0///Assigned.Stage: 3///GRADE: 3 ///Debulk: Optimal///CA125.POST: 10///response.0.NR..1.CR.: 1///X: NA///X.1: NA///X.2: NA
1
(Other)
18
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Value
An expression set
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