Uniquorn: Identification of cancer cell lines based on their weighted mutational/ variational fingerprint

This packages enables users to identify cancer cell lines. Cancer cell line misidentification and cross-contamination reprents a significant challenge for cancer researchers. The identification is vital and in the frame of this package based on the locations/ loci of somatic and germline mutations/ variations. The input format is vcf/ vcf.gz and the files have to contain a single cancer cell line sample (i.e. a single member/genotype/gt column in the vcf file). The implemented method is optimized for the Next-generation whole exome and whole genome DNA-sequencing technology. RNA-seq data is very likely to work as well but hasn't been rigiously tested yet. Panel-seq will require manual adjustment of thresholds

Package details

AuthorRaik Otto
Bioconductor views ExomeSeq ImmunoOncology StatisticalMethod WholeGenome
Maintainer'Raik Otto' <raik.otto@hu-berlin.de>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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Uniquorn documentation built on Nov. 8, 2020, 8:07 p.m.