Expression levels of mRNA molecules are regulated by different processes, comprising inhibition or activation by transcription factors and posttranscriptional degradation by microRNAs. birta (Bayesian Inference of Regulation of Transcriptional Activity) uses the regulatory networks of TFs and miRNAs together with mRNA and miRNA expression data to predict switches in regulatory activity between two conditions. A Bayesian network is used to model the regulatory structure and MarkovChainMonteCarlo is applied to sample the activity states.
Package details 


Author  Benedikt Zacher, Khalid Abnaof, Stephan Gade, Erfan Younesi, Achim Tresch, Holger Froehlich 
Bioconductor views  GeneExpression GraphAndNetwork Microarray Sequencing Transcription 
Maintainer  Benedikt Zacher <zacher@lmb.unimuenchen.de>, Holger Froehlich <frohlich@bit.unibonn.de> 
License  GPL (>= 2) 
Version  1.20.0 
Package repository  View on Bioconductor 
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