Description Usage Arguments Value Author(s) References Examples

R implementation of the PhenoGraph algorithm

A simple R implementation of the [PhenoGraph](http://www.cell.com/cell/abstract/S0092-8674(15)00637-6) algorithm, which is a clustering method designed for high-dimensional single-cell data analysis. It works by creating a graph ("network") representing phenotypic similarities between cells by calclating the Jaccard coefficient between nearest-neighbor sets, and then identifying communities using the well known [Louvain method](https://sites.google.com/site/findcommunities/) in this graph.

This function is developed by Hao Chen and updated by Yuting Dai.

1 | ```
Rphenograph(data, k = 30)
``` |

`data` |
matrix; input data matrix |

`k` |
integer; number of nearest neighbours (default:30) |

a list contains an igraph graph object for `graph_from_data_frame`

and a communities object, the operations of this class contains:

`print` |
returns the communities object itself, invisibly. |

`length` |
returns an integer scalar. |

`sizes` |
returns a numeric vector. |

`membership` |
returns a numeric vector, one number for each vertex in the graph that was the input of the community detection. |

`modularity` |
returns a numeric scalar. |

`algorithm` |
returns a character scalar. |

`crossing` |
returns a logical vector. |

`is_hierarchical` |
returns a logical scalar. |

`merges` |
returns a two-column numeric matrix. |

`cut_at` |
returns a numeric vector, the membership vector of the vertices. |

`as.dendrogram` |
returns a dendrogram object. |

`show_trace` |
returns a character vector. |

`code_len` |
returns a numeric scalar for communities found with the InfoMAP method and NULL for other methods. |

`plot` |
for communities objects returns NULL, invisibly. |

cluster information

Hao Chen <chen_hao@immunol.a-star.edu.sg>

Jacob H. Levine and et.al. Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis. Cell, 2015.

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