pwOmics: Pathway-based data integration of omics data

pwOmics performs pathway-based level-specific data comparison of matching omics data sets based on pre-analysed user-specified lists of differential genes/transcripts and proteins. A separate downstream analysis of proteomic data including pathway identification and enrichment analysis, transcription factor identification and target gene identification is opposed to the upstream analysis starting with gene or transcript information as basis for identification of upstream transcription factors and regulators. The cross-platform comparative analysis allows for comprehensive analysis of single time point experiments and time-series experiments by providing static and dynamic analysis tools for data integration.

AuthorAstrid Wachter <Astrid.Wachter@med.uni-goettingen.de>
Date of publicationNone
MaintainerAstrid Wachter <Astrid.Wachter@med.uni-goettingen.de>
LicenseGPL (>= 2)
Version1.6.0

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Man pages

addFeedbackLoops: Add feedback loops from target genes to proteins/TFs if...

clusterTimeProfiles: Clustering of time profiles.

consDynamicNet: Dynamic analysis.

createBiopaxnew: Create a new Biopax model containing all database...

createIntIDs: Create internal IDs.

enrichPWs: Pathway enrichment - downstream analysis.

enrichTFs: Transcription factor enrichment - upstream analysis.

findxneighborsoverlap: Find overlap of next neighbors of transcription factors in...

findxnextneighbors: Find next neighbors of transcription factors in identified...

genfullConsensusGraph: Combine SteinerNet with bipartite graph to get full consensus...

genGenelists: Generate genelists from pathway databases.

genGenelistssub: Generate internally genelists from pathway databases.

genIntIDs: Internal function for generation of pathway database specific...

getAlias_Ensemble: Get Gene Symbols from Ensemble Gene Accession IDs.

getAliasfromSTRINGIDs: Map alias names to STRING IDs of consensus graph.

getBiopaxModel: Get upstream regulators of identified transcription factors.

getbipartitegraphInfo: Get TF-target gene information for the consensus graph.

getConsensusSTRINGIDs: Get consensus graph in STRING IDs.

getDS_PWs: Get downstream analysis pathways.

getDS_TFs: Get downstream analysis transcription factors in pathways.

getDS_TGs: Get downstream analysis target genes of TFs found in...

getFCsplines: Get fold change splines.

getGenesIntersection: Get genes intersection for the omics data on the different...

getOmicsallGeneIDs: Get all gene IDs.

getOmicsallProteinIDs: Get all protein IDs.

getOmicsDataset: Get Omics dataset.

getOmicsTimepoints: Get Omics timepoints.

getProteinIntersection: Get protein intersection for the omics data on the different...

getSTRING_graph: Generate STRING PPI graph.

getTFIntersection: Get TF intersection for the omics data on the different time...

gettpIntersection: Get omics data intersection on the three levels. Get...

getUS_PWs: Get upstream pathways of identified transcription factors.

getUS_regulators: Get upstream regulators of identified transcription factors.

getUS_TFs: Get upstream TFs.

identifyPWs: Identify pathway IDs and pathway names of differentially...

identifyPWTFTGs: Identify TFs in enriched pathways and their target genes -...

identifyRsofTFs: Identify regulators of enriched transcription factors -...

identifyTFs: Transcription factor identification.

identPWsofTFs: Identification of pathways containing the transcription...

identRegulators: Identify overlapping upstream regulators of x transcription...

identTFs: This function provides a data.table of upstream transcription...

identTFTGsinPWs: Prepare OmicsData object for pathway information.

loadGenelists: Loading of genelists

loadPWs: Load pathway database information.

OmicsExampleData: Omics example dataset.

plotConsDynNet: Plot inferred net based on analysis analysis.

plotConsensusGraph: Plot consensus graph(s) from static analysis.

plotConsensusProfiles: Plot consensus graph profiles of static consensus molecules.

plotTimeProfileClusters: Plot time profile clusters of dynamic analysis result.

predictFCvals: Prediction of continous data points via smoothing splines.

preparePWinfo: Prepare OmicsData object for pathway information.

print.OmicsData: Print an OmicsData object.

PWidentallprots: Identification of pathwayIDs and pathway names for all...

PWidentallprotssub: Internal subfunction for all protein pathway identification.

PWidenttps: Identification of pathwayIDs and pathway names for proteins...

pwIntOmics-package: Pathway-based data integration of omics data

readOmics: Read in omics data.

readPWdata: Read in pathway database data needed for pathway...

readTFdata: Reads in chosen transcription factor target database...

readTFtargets: Read in matching transcription factor target gene pairs.

selectPWsofTFs: Select pathways with more than x TFs

staticConsensusNet: Static analysis.

SteinerTree_cons: Steiner tree algorithm.

TFidentallgenes: Identification of upstream transcription factors for all...

TFidenttps: Identification of upstream transcription factors.

Files in this package

pwOmics/DESCRIPTION
pwOmics/NAMESPACE
pwOmics/NEWS
pwOmics/R
pwOmics/R/pwOmics_consensus_analysis.R pwOmics/R/pwOmics_downstream_analysis.R pwOmics/R/pwOmics_example_dataset.R pwOmics/R/pwOmics_get_functions.R pwOmics/R/pwOmics_helper_functions.R pwOmics/R/pwOmics_print.R pwOmics/R/pwOmics_read_data.R pwOmics/R/pwOmics_time_profiles.R pwOmics/R/pwOmics_upstream_analysis.R pwOmics/R/pwOmics_vizualisation_functions.R
pwOmics/build
pwOmics/build/vignette.rds
pwOmics/data
pwOmics/data/OmicsExampleData.RData
pwOmics/inst
pwOmics/inst/doc
pwOmics/inst/doc/pwOmics.R
pwOmics/inst/doc/pwOmics.Rnw
pwOmics/inst/doc/pwOmics.pdf
pwOmics/inst/extdata
pwOmics/inst/extdata/Genelists
pwOmics/inst/extdata/Genelists/Genelist_biocarta.RData
pwOmics/inst/extdata/chea-background.csv
pwOmics/inst/unitTests
pwOmics/inst/unitTests/provided_TF_genes.txt
pwOmics/inst/unitTests/pwIntOmics_exported.R
pwOmics/inst/unitTests/pwIntOmics_internal.R
pwOmics/man
pwOmics/man/OmicsExampleData.Rd pwOmics/man/PWidentallprots.Rd pwOmics/man/PWidentallprotssub.Rd pwOmics/man/PWidenttps.Rd pwOmics/man/SteinerTree_cons.Rd pwOmics/man/TFidentallgenes.Rd pwOmics/man/TFidenttps.Rd pwOmics/man/addFeedbackLoops.Rd pwOmics/man/clusterTimeProfiles.Rd pwOmics/man/consDynamicNet.Rd pwOmics/man/createBiopaxnew.Rd pwOmics/man/createIntIDs.Rd pwOmics/man/enrichPWs.Rd pwOmics/man/enrichTFs.Rd pwOmics/man/findxneighborsoverlap.Rd pwOmics/man/findxnextneighbors.Rd pwOmics/man/genGenelists.Rd pwOmics/man/genGenelistssub.Rd pwOmics/man/genIntIDs.Rd pwOmics/man/genfullConsensusGraph.Rd pwOmics/man/getAlias_Ensemble.Rd pwOmics/man/getAliasfromSTRINGIDs.Rd pwOmics/man/getBiopaxModel.Rd pwOmics/man/getConsensusSTRINGIDs.Rd pwOmics/man/getDS_PWs.Rd pwOmics/man/getDS_TFs.Rd pwOmics/man/getDS_TGs.Rd pwOmics/man/getFCsplines.Rd pwOmics/man/getGenesIntersection.Rd pwOmics/man/getOmicsDataset.Rd pwOmics/man/getOmicsTimepoints.Rd pwOmics/man/getOmicsallGeneIDs.Rd pwOmics/man/getOmicsallProteinIDs.Rd pwOmics/man/getProteinIntersection.Rd pwOmics/man/getSTRING_graph.Rd pwOmics/man/getTFIntersection.Rd pwOmics/man/getUS_PWs.Rd pwOmics/man/getUS_TFs.Rd pwOmics/man/getUS_regulators.Rd pwOmics/man/getbipartitegraphInfo.Rd pwOmics/man/gettpIntersection.Rd pwOmics/man/identPWsofTFs.Rd pwOmics/man/identRegulators.Rd pwOmics/man/identTFTGsinPWs.Rd pwOmics/man/identTFs.Rd pwOmics/man/identifyPWTFTGs.Rd pwOmics/man/identifyPWs.Rd pwOmics/man/identifyRsofTFs.Rd pwOmics/man/identifyTFs.Rd pwOmics/man/loadGenelists.Rd pwOmics/man/loadPWs.Rd pwOmics/man/plotConsDynNet.Rd pwOmics/man/plotConsensusGraph.Rd pwOmics/man/plotConsensusProfiles.Rd pwOmics/man/plotTimeProfileClusters.Rd pwOmics/man/predictFCvals.Rd pwOmics/man/preparePWinfo.Rd pwOmics/man/print.OmicsData.Rd pwOmics/man/pwIntOmics-package.Rd pwOmics/man/readOmics.Rd pwOmics/man/readPWdata.Rd pwOmics/man/readTFdata.Rd pwOmics/man/readTFtargets.Rd pwOmics/man/selectPWsofTFs.Rd pwOmics/man/staticConsensusNet.Rd
pwOmics/tests
pwOmics/tests/runTests.R
pwOmics/vignettes
pwOmics/vignettes/ConsensusGraphs_1.pdf
pwOmics/vignettes/ConsensusGraphs_2.pdf
pwOmics/vignettes/TimeProfiles.pdf
pwOmics/vignettes/dynConsensusNet_2.pdf
pwOmics/vignettes/pwOmics.Rnw
pwOmics/vignettes/pwOmics_vignette.bib
pwOmics/vignettes/references.bib
pwOmics/vignettes/updown.pdf
pwOmics/vignettes/workflow.pdf

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