Description Usage Arguments Value References Examples
View source: R/targetingMatrix.R
Function to the calculation of the number of Nucleotids at three positions before and after a mutation
1 | targetingMatrix(data_tab2, data_tab_germline, data_tab7)
|
data_tab2 |
Column V_Region in th IMGT table 2 |
data_tab_germline |
Output from function germlineReconstr() |
data_tab7 |
Column V_Region in th IMGT table 7 |
Result is a list of 8 matrices with the numbers of nucleotides at three positions before and after a mutation from A, T, C, and G, as well as in a mutated sequence and in the germline sequence
Spencer J. and Dunn-Walters DK. Hypermutation at A-T base pairs: the A nucleotidereplacement spectrum is affected by adjacent nucleotides and there is no reverse comple-mentary of sequences flanking muated A and T nucleotides.J Immunol, 175(8):5170 - 5177,2005.
Zuckerman NS., Hazanov H., Barak M., Edelman H., Hess S., Shcolnik H., Dunn-Walters D.,and Mehr R. Somatic hypermutation and antigen-driven selection of B cells are altered inautoimmune diseases.J Autoimmun, 35(4):325 - 335, 2010. doi: 10.1016/j.jaut.2010.07.004.
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