COMBIA: Synergy/Antagonism Analyses of Drug Combinations

A comprehensive synergy/antagonism analyses of drug combinations with quality graphics and data. The analyses can be performed by Bliss independence and Loewe additivity models. 'COMBIA' provides improved statistical analysis and makes only very weak assumption of data variability while calculating bootstrap intervals (BIs). It is based on heteroscedasticity controlled resampling (bootstrapping) and includes a global (omnibus) test. Finally, package shows analyzed data, 2D and 3D plots ready to use in research publications. 'COMBIA' does not require manual data entry. Data can be directly input from wet lab experimental platforms for example fluostar, automated robots etc. One only needs to call a single function, analyzeCOMBO(), to perform all analysis (examples are provided with sample data).

install.packages("COMBIA")

Try the COMBIA package in your browser