COMBIA: Synergy/Antagonism Analyses of Drug Combinations

A comprehensive synergy/antagonism analyses of drug combinations with quality graphics and data. The analyses can be performed by Bliss independence and Loewe additivity models. COMBIA provides improved statistical analysis and makes only very weak assumption of data variability while calculating bootstrap intervals (BIs). Finally, package saves analyzed data, 2D and 3D plots ready to use in research publications. COMBIA does not require manual data entry. Data can be directly input from wetlab experimental platforms for example fluostar, automated robots etc. One needs to call a single function only to perform all analysis (examples are provided with sample data).

Install the latest version of this package by entering the following in R:
install.packages("COMBIA")
AuthorMuhammad Kashif
Date of publication2015-07-26 18:53:01
MaintainerMuhammad Kashif <Muhammad.Kashif@medsci.uu.se>
LicenseGPL (>= 2)
Version1.0-4

View on CRAN

Functions

applyBliss Man page
applyLoewe Man page
calculateSynergy Man page
combineDataFromMultipleFiles Man page
createUniquePertbs Man page
cVCal Man page
extractKey Man page
extractReplicateValues Man page
extractValuesFromRange Man page
loeweModel Man page
readFile Man page
readFluostarPlates Man page
readFMCAValues Man page
readMacSynergyValues Man page
readOtherValues Man page
removeOutliers Man page
selectPlate Man page
synAntPlot Man page
synergySignificant Man page

Questions? Problems? Suggestions? or email at ian@mutexlabs.com.

Please suggest features or report bugs with the GitHub issue tracker.

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