applyLoewe: This function calculates Loewe synergy/antagonism and...

In COMBIA: Synergy/Antagonism Analyses of Drug Combinations

Description

This function calculates Loewe synergy/antagonism and associated BIs

Usage

applyLoewe(rawDataPreProcessed, xConcentration, yConcentration, nBoot)

Arguments

rawDataPreProcessed	Raw preprocessed experimental data
xConcentration	X drug concentrations
yConcentration	Y drug concentrations
nBoot	Number of times to bootstrap

Value

Three lists, first list consisting of Loewe Synergy/Antagonism, lower bound of BI and upper bound of BI. 2nd list consists of global BI for maximum synergy and 3rd list consists of global BI of maximum antagonistic combination.

Author(s)

Muhammad kashif

Examples

## Not run: 
dataFile <- system.file("extdata", "rawDataPreProcessed.csv", package="COMBIA")
dataSample <- read.csv(dataFile, header=FALSE )
xConc  <- c(0.00,  0.20,  0.39,  0.78,  1.56,3.12,  6.25, 12.50, 25.00, 50) 
yConc <- c(128,  64,  32,  16,   8,   4,   2,   0)
noOFBoot <- 500 # a large number is recomended
rslt <- applyLoewe(as.matrix(dataSample), xConc, yConc, noOFBoot)

## End(Not run)

COMBIA documentation built on May 2, 2019, 7:23 a.m.