multisepCrisprList: Example Multisep t-test CRISPR vs XPR results object.

In MultiSEp: Predict Synthetic Lethality and Other Gene Dependency Relationships from Multiomics Data

Example Multisep t-test CRISPR vs XPR results object.

Description

A data frame containing results from multiSEp t-test based analysis of gene expression and CRISPR.

Usage

data("multisepCrisprList")

Format

A data frame with 1428 observations (gene pairs) across 25 variables (columns).

mRNA_gene

Gene id of the gene expression gene

crispr_gene

Gene id of the crispr gene

num_modes

Number of gene expression clusters

nMode1

Number of samples in each gene expression cluster 1

nMode2

Number of samples in each gene expression cluster 2

nMode3

Number of samples in each gene expression cluster 3

nMode4

Number of samples in each gene expression cluster 4

nMode5

Number of samples in each gene expression cluster 5

mMode1

Mean CRISPR score of the crispr gene in each gene expression cluster 1

mMode2

Mean CRISPR score of the crispr gene in each gene expression cluster 2

mMode3

Mean CRISPR score of the crispr gene in each gene expression cluster 3

mMode4

Mean CRISPR score of the crispr gene in each gene expression cluster 4

mMode5

Mean CRISPR score of the crispr gene in each gene expression cluster 5

shift2_1

Fold-change of CRISPR scores between expression modes 2 and 1

shift3_2

Fold-change of CRISPR scores between expression modes 3 and 2

shift4_3

Fold-change of CRISPR scores between expression modes 4 and 3

shift5_4

Fold-change of CRISPR scores between expression modes 5 and 4

pvalue2_1

P-value of CRISPR score difference between expression modes 2 and 1

pvalue3_2

P-value of CRISPR score difference between expression modes 3 and 2

pvalue4_3

P-value of CRISPR score difference between expression modes 4 and 3

pvalue5_4

P-value of CRISPR score difference between expression modes 5 and 4

qvalue2_1

Q-value of CRISPR score difference between expression modes 2 and 1

qvalue3_2

Q-value of CRISPR score difference between expression modes 3 and 2

qvalue4_3

Q-value of CRISPR score difference between expression modes 4 and 3

qvalue5_4

Q-value of CRISPR score difference between expression modes 5 and 4

Source

Derived from analysis of data taken from DepMap 2024Q2 \Sexpr[results=rd]{tools:::Rd_expr_doi("10.25452/figshare.plus.25880521.v1")}

References

Tsherniak A., Vazquez F., Montgomery P.G., Weir B.A., Kryukov G., Cowley G.S., Gill S., Harrington W.F., Pantel S., Krill-Burger J.M. et al. . Defining a cancer dependency map. Cell. 2017; 170:564-576. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1016/j.cell.2017.06.010")}

Examples

data(multisepCrisprList)
multisepCrisprList[1:10,]

MultiSEp documentation built on Aug. 27, 2026, 5:07 p.m.