R/corAndPvalue.R

Defines functions bicorAndPvalue corAndPvalue

Documented in bicorAndPvalue corAndPvalue

# Functions to calculate correlation and corresponding p-values. Geared towards cor p-values of large
# matrices where varying numbers of missing data make the number of observations vary for each pair of
# columns.
corAndPvalue = function(x, y = NULL, 
                        use = "pairwise.complete.obs", 
                        alternative = c("two.sided", "less", "greater"), 
                        ...)
{ 
  ia = match.arg(alternative);
  cor = cor(x, y, use = use, ...);
  x = as.matrix(x);
  finMat = !is.na(x)
  if (is.null(y))
  {
    np = t(finMat) %*% finMat;
  } else {
    y = as.matrix(y);
    np = t(finMat) %*% (!is.na(y));
  }
  Z = 0.5 * log( (1+cor)/(1-cor) ) * sqrt(np-2);
  if (ia=="two.sided")
  {
    T = sqrt(np - 2) * abs(cor)/sqrt(1 - cor^2)
    p = 2*pt(T, np - 2, lower.tail = FALSE);
  } else if (ia=="less")
  {
    T = sqrt(np - 2) * cor/sqrt(1 - cor^2)
    p = pt(T, np - 2, lower.tail = TRUE)
  } else if (ia=="greater")
  {
    T = sqrt(np - 2) * cor/sqrt(1 - cor^2)
    p = pt(T, np - 2, lower.tail = FALSE)
  }

  list(cor = cor, p = p, Z = Z, t = T, nObs = np);
}

bicorAndPvalue = function(x, y = NULL, use = "pairwise.complete.obs", 
                          alternative = c("two.sided", "less", "greater"), 
                          ...)
{
  ia = match.arg(alternative);
  cor = bicor(x, y, use = use, ...);
  x = as.matrix(x);
  finMat = !is.na(x)
  if (is.null(y))
  {
    np = t(finMat) %*% finMat;
  } else {
    y = as.matrix(y);
    np = t(finMat) %*% (!is.na(y));
  }
  Z = 0.5 * log( (1+cor)/(1-cor) ) * sqrt(np-2);
  if (ia=="two.sided")
  {
    T = sqrt(np - 2) * abs(cor)/sqrt(1 - cor^2)
    p = 2*pt(T, np - 2, lower.tail = FALSE);
  } else if (ia=="less")
  {
    T = sqrt(np - 2) * cor/sqrt(1 - cor^2)
    p = pt(T, np - 2, lower.tail = TRUE)
  } else if (ia=="greater")
  {
    #Z = 0.5 * log( (1+cor)/(1-cor) ) * sqrt(np-3);
    T = sqrt(np - 2) * cor/sqrt(1 - cor^2)
    p = pt(T, np - 2, lower.tail = FALSE)
  }

  list(bicor = cor, p = p, Z = Z, t = T, nObs = np);
}

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WGCNA documentation built on March 1, 2021, 1:05 a.m.