ldInitLocPeak: Find the Location of Maximum, Error Spending Approach

Description Usage Arguments Details Value Author(s) References See Also Examples

View source: R/refinedBoundaries.R

Description

Calculate the location of maximal type I error of secondary endpoint.

Usage

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ldInitLocPeak(alpha, tVec, cvec, type = 2, initIntvl = c(0.8, 4),
  initNrep = 10)

Arguments

alpha

type I error.

tVec

information vector.

cvec

primary group sequential boundary.

type

type of the test procedure for the secondary endpoint. O'Brien- Fleming (OBF) type error spending funciton is 1, Pocock (POC) type error spending funciton is 2.

initIntvl

computing paramter, a pair of numbers containing the end-points of the interval to be searched for the root.

initNrep

computing paramter, number of replica.

Details

This function searches the location of maximal type I error of secondary endpoint by using the error spending approach.

Value

location of maximum, a number between 1 and the number of interims.

Author(s)

Jiangtao Gou

References

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2017+). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, to appear.

See Also

ldSecondaryBoundary, initLocBeak

Examples

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#require(mvtnorm)
#require(ldbounds)
#K <- 6;
#tVec <- c(140,328,453,578,659,1080)/1080;
#alpha = 0.025;
#cvec.obf <- bounds(tVec,iuse=c(1),alpha=c(alpha));
#cvec <- cvec.obf$upper.bounds;
#loc <- ldInitLocPeak(alpha,tVec,cvec,type=2,initIntvl=c(0.9,4),initNrep=1)

gsrsb documentation built on May 29, 2017, 7:12 p.m.