Description Usage Arguments Details Value Author(s) References Examples

View source: R/refinedBoundaries.R

Primary boundaries, refined secondary boundaries, and nominal significance for the secondary endpoint are listed.

1 2 | ```
refinedBoundary(alpha, tVec, pOBF = TRUE, sOBF = FALSE, LanDeMets = FALSE,
SpeedQuality = "fast", digits = 2)
``` |

`alpha` |
type I error probability. |

`tVec` |
vector of relative information levels. The last element in the vector is 1. |

`pOBF` |
type of primary boundary, |

`sOBF` |
type of secondary boundary, |

`LanDeMets` |
type of boundary, |

`SpeedQuality` |
quality-speed tradeoff parameter. Choices are |

`digits` |
number of digits after decimal point for primary and secondary boundaries. |

This function gives a list including primary boundary, refined secondary boundary, and the nominal significance for the secondary endpoint.
When the choice of parameter `SpeedQuality`

is `fastest`

, `fast`

, `acceptable`

, or `normal`

,
the default number of digits for boundaries is 2. When the choice of parameter `SpeedQuality`

is `good`

or `stable`

, the default number of digits for boundaries is 2.
The number of digits for boundaries after decimal point can also be specified through parameter `digits`

.
The number of digits for the nominal significance depends on parameter `alpha`

.

a result list including primary boundary, refined secondary boundary, and the nominal significance for the secondary endpoint.

Jiangtao Gou

Glimm, E., Maurer, W., and Bretz, F. (2010). Hierarchical testing of multiple endpoints in group-sequential trials. *Statistics in Medicine* **29**, 219-228.

Hung, H. M. J., Wang, S.-J., and O'Neill, R. (2007). Statistical considerations for testing multiple endpoints in group sequential or adaptive clinical trials. *Journal of Biopharmaceutical Statistics* **17**, 1201-1210.

Jennison, C. and Turnbull, B. W. (2000). *Group Sequential Methods with Applications to Clinical Trials*. Chapman and Hall/CRC, New York.

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. *Biometrika* **70**, 659-663.

O'Brien, P. C., and Fleming, T. R. (1979). A multiple testing procedure for clinical trials. *Biometrics* **35**, 549-556.

Pocock, S. J. (1977). Group sequential methods in the design and analysis of clinical trials. *Biometrika* **64**, 191-199.

Tamhane, A. C., Mehta, C. R., and Liu, L. (2010). Testing a primary and a secondary endpoint in a group sequential design. *Biometrics* **66**, 1174-1184.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2017+). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. *Biometrics*, to appear.

1 2 3 4 5 6 | ```
require(mvtnorm)
require(ldbounds)
result <- refinedBoundary(alpha=0.05,tVec=c(0.2,0.6,1),SpeedQuality="fastest")
result$primaryBoundary
result$secondaryBoundary
result$nomialSignificance
``` |

gsrsb documentation built on May 29, 2017, 7:12 p.m.

Embedding an R snippet on your website

Add the following code to your website.

For more information on customizing the embed code, read Embedding Snippets.