nominalSig: Calculate Nominal Significance, Standard Approach

Description Usage Arguments Details Value Author(s) References See Also Examples

View source: R/refinedBoundaries.R

Description

Nominal significance for the secondary endpoint are calculated by using the standard (original) approach.

Usage

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nominalSig(gammaVec, cvec)

Arguments

gammaVec

square root of information.

cvec

group sequential boundary.

Details

This function calculates he nominal significance level of any given boundary.

Value

nominal significance

Author(s)

Jiangtao Gou

References

O'Brien, P. C., and Fleming, T. R. (1979). A multiple testing procedure for clinical trials. Biometrics 35, 549-556.

Pocock, S. J. (1977). Group sequential methods in the design and analysis of clinical trials. Biometrika 64, 191-199.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2017+). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, to appear.

See Also

ldNominalSig, secondaryBoundaryVecOrig

Examples

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#require(mvtnorm)
#require(ldbounds)
#nSig <- nominalSig(gammaVec=c(sqrt(1/3),1),cvec=c(2.2,1.8))

gsrsb documentation built on May 29, 2017, 7:12 p.m.