Description Usage Arguments Details Value Author(s) References See Also Examples

View source: R/refinedBoundaries.R

Nominal significance for the secondary endpoint are calculated by using the standard (original) approach.

1 | ```
nominalSig(gammaVec, cvec)
``` |

`gammaVec` |
square root of information. |

`cvec` |
group sequential boundary. |

This function calculates he nominal significance level of any given boundary.

nominal significance

Jiangtao Gou

O'Brien, P. C., and Fleming, T. R. (1979). A multiple testing procedure for clinical trials. *Biometrics* **35**, 549-556.

Pocock, S. J. (1977). Group sequential methods in the design and analysis of clinical trials. *Biometrika* **64**, 191-199.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2017+). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. *Biometrics*, to appear.

`ldNominalSig`

, `secondaryBoundaryVecOrig`

1 2 3 | ```
#require(mvtnorm)
#require(ldbounds)
#nSig <- nominalSig(gammaVec=c(sqrt(1/3),1),cvec=c(2.2,1.8))
``` |

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