Nominal significance for the secondary endpoint are calculated by using the standard (original) approach.
square root of information.
group sequential boundary.
This function calculates he nominal significance level of any given boundary.
O'Brien, P. C., and Fleming, T. R. (1979). A multiple testing procedure for clinical trials. Biometrics 35, 549-556.
Pocock, S. J. (1977). Group sequential methods in the design and analysis of clinical trials. Biometrika 64, 191-199.
Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2017+). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, to appear.
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#require(mvtnorm) #require(ldbounds) #nSig <- nominalSig(gammaVec=c(sqrt(1/3),1),cvec=c(2.2,1.8))
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