ldPrimaryBoundary | R Documentation |
Primary boundaries calculation of Lan-DeMets OBF and POC.
ldPrimaryBoundary(tVec, alpha, type = 1, initIntvl = c(0.8, 8))
tVec |
a vector of information, gammaVec = sqrt(tVec). |
alpha |
significance level |
type |
type of sequential procedure. OBF is 1, POC is 2. |
initIntvl |
paramter for function uniroot (two numbers) |
a vector of primary boundaries.
Jiangtao Gou
Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.
Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.
Gou, J. (2023). Trigger strategy in repeated tests on multiple hypotheses. Statistics in Biopharmaceutical Research, 15(1), 133–140.
primaryBoundary
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