Description Usage Arguments Value Author(s) References See Also

View source: R/refinedBoundaries.R

Primary boundaries calculation of Lan-DeMets OBF and POC.

1 | ```
ldPrimaryBoundary(tVec, alpha, type = 1, initIntvl = c(0.8, 8))
``` |

`tVec` |
a vector of information, gammaVec = sqrt(tVec). |

`alpha` |
significance level |

`type` |
type of sequential procedure. OBF is 1, POC is 2. |

`initIntvl` |
paramter for function uniroot (two numbers) |

a vector of primary boundaries.

Jiangtao Gou

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. *Biometrika* **70**, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2017+). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. *Biometrics*, to appear.

gsrsb documentation built on May 29, 2017, 7:12 p.m.

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