ldPrimaryBoundary: Calculate Primary Boundaries, the Error Spending Approach

In gsrsb: Group Sequential Refined Secondary Boundary

Calculate Primary Boundaries, the Error Spending Approach

Description

Primary boundaries calculation of Lan-DeMets OBF and POC.

Usage

ldPrimaryBoundary(tVec, alpha, type = 1, initIntvl = c(0.8, 8))

Arguments

tVec	a vector of information, gammaVec = sqrt(tVec).
alpha	significance level
type	type of sequential procedure. OBF is 1, POC is 2.
initIntvl	paramter for function uniroot (two numbers)

Value

a vector of primary boundaries.

Author(s)

Jiangtao Gou

References

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.

Gou, J. (2023). Trigger strategy in repeated tests on multiple hypotheses. Statistics in Biopharmaceutical Research, 15(1), 133–140.

See Also

primaryBoundary

gsrsb documentation built on July 9, 2023, 6:02 p.m.