ldSecControl: Difference between the Error Rate and Significance Level, the...

Description Usage Arguments Value Author(s) References See Also

View source: R/refinedBoundaries.R

Description

Calculate the difference between the error rate and significance level for the secondary endpoint, Lan-DeMets error spending approach.

Usage

1
ldSecControl(ap, alpha, cvec, tVec, ExtrmLoc, type = 2)

Arguments

ap

significance level for the primary endpoint

alpha

targeted significance level for the secondary endpoint

cvec

a vector of calculated primary boundaries

tVec

a vector of information, gammaVec = sqrt(tVec)

ExtrmLoc

an integer between 1 and K, locate the maximum of type I error of secondary endpoint

type

type of sequential procedures. Type 1 OBF d, Type 2 POC d.

Value

difference between alpha and the calculated error rate.

Author(s)

Jiangtao Gou

References

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2017+). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, to appear.

See Also

secControl


gsrsb documentation built on May 29, 2017, 7:12 p.m.