Description Usage Arguments Value Author(s) References See Also

View source: R/refinedBoundaries.R

Calculate the difference between the error rate and significance level for the secondary endpoint, Lan-DeMets error spending approach.

1 | ```
ldSecControl(ap, alpha, cvec, tVec, ExtrmLoc, type = 2)
``` |

`ap` |
significance level for the primary endpoint |

`alpha` |
targeted significance level for the secondary endpoint |

`cvec` |
a vector of calculated primary boundaries |

`tVec` |
a vector of information, gammaVec = sqrt(tVec) |

`ExtrmLoc` |
an integer between 1 and K, locate the maximum of type I error of secondary endpoint |

`type` |
type of sequential procedures. Type 1 OBF d, Type 2 POC d. |

difference between alpha and the calculated error rate.

Jiangtao Gou

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. *Biometrika* **70**, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2017+). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. *Biometrics*, to appear.

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