ldSecControl: Difference between the Error Rate and Significance Level, the...

In gsrsb: Group Sequential Refined Secondary Boundary

Difference between the Error Rate and Significance Level, the Error Spending Approach

Description

Calculate the difference between the error rate and significance level for the secondary endpoint, Lan-DeMets error spending approach.

Usage

ldSecControl(ap, alpha, cvec, tVec, ExtrmLoc, type = 2)

Arguments

ap	significance level for the primary endpoint
alpha	targeted significance level for the secondary endpoint
cvec	a vector of calculated primary boundaries
tVec	a vector of information, gammaVec = sqrt(tVec)
ExtrmLoc	an integer between 1 and K, locate the maximum of type I error of secondary endpoint
type	type of sequential procedures. Type 1 OBF d, Type 2 POC d.

Value

difference between alpha and the calculated error rate.

Author(s)

Jiangtao Gou

References

Lan, K. K. G., and Demets, D. L. (1983). Discrete sequential boundaries for clinical trials. Biometrika 70, 659-663.

Tamhane, A. C., Gou, J., Jennison, C., Mehta, C. R., and Curto, T. (2018). A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Biometrics, 74(1), 40-48.

See Also

secControl

gsrsb documentation built on July 9, 2023, 6:02 p.m.