lipid.cad.scores: Genetic risk scores for serum lipid levels and coronary...

In gtx: Genetics ToolboX

Description

Risk scores parameterised using GWAS meta-analysis results published by Waterworth et al. (Arteriosclerosis, Thrombosis, and Vascular Biology 2010). There are scores for three different lipid level phenotypes (High Density Lipoprotein HDL; Low Density Lipoprotein LDL; Triglycerides TG), all parameterised using SNPs reported in previous studies, with effect sizes estimated using the data of Waterworth et al. (2010 Table 1). For each SNP the outcome, estimated effect on risk of coronary artery disease (CAD), from a case/control collection of 9633 cases and 38684 controls, was reported by Waterworth et al. (2010 Table 4).

Usage

lipid.cad.scores

Format

A data frame suitable for use with other functions in this package.

These scores are called HDL, LDL and TG, and have coefficients in change in natural log transformed lipid level per coded allele.

The coefficients for outcome effect are in natural log odds ratio per coded allele.

Source

For the publication by Waterworth et al. from which these data were extracted see http://dx.doi.org/10.1161/ATVBAHA.109.201020.

gtx documentation built on May 2, 2019, 5:08 a.m.