calc_dermal_equiv: Calculate Dermal Equivalent Dose

In httk: High-Throughput Toxicokinetics

Calculate Dermal Equivalent Dose

Description

This functions converts a steady state plasma concetration for a given dermal exposure scenario to an equivalent steady state media concentration for a single dose.

Usage

calc_dermal_equiv(
  conc,
  chem.name = NULL,
  chem.cas = NULL,
  dtxsid = NULL,
  parameters = NULL,
  days = 20,
  doses.per.day = 3,
  skin_depth = 0.3,
  skin.pH = 7,
  Vmedia = 0.001,
  Fskinexposed = 0.1,
  ...
)

Arguments

conc	Bioactive in vitro concentration, arbitrary units.
chem.name	Either the chemical name or the CAS number must be specified.
chem.cas	Either the CAS number or the chemical name must be specified.
dtxsid	EPA's DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs
parameters	Parameters from parameterize_dermal_pbtk.
days	Number of days of simulation.
doses.per.day	Number of doses per day.
skin_depth	Skin depth, cm.
skin.pH	pH of skin/dermis.
Vmedia	Volume of media, L, used when parameters are not given.
Fskinexposed	Fraction of total skin exposed, used when parameters are not given.
...	Additional parameters passed to solve_dermal_pbtk.

Details

Returned dose is dependent on doses.per.day.

Value

Equivalent dose in specified units, default of mg/kg BW/day.

Author(s)

Annabel Meade

httk documentation built on Aug. 29, 2025, 5:16 p.m.