get_wetmore_css: Get literature Css (deprecated).

In httk: High-Throughput Toxicokinetics

Get literature Css (deprecated).

Description

This function is included for backward compatibility. It calls get_lit_css which retrieves a steady-state plasma concentration as a result of infusion dosing from the Wetmore et al. (2012) and (2013) publications and other literature.

Usage

get_wetmore_css(
  chem.cas = NULL,
  chem.name = NULL,
  daily.dose = 1,
  which.quantile = 0.95,
  species = "Human",
  clearance.assay.conc = NULL,
  output.units = "mg/L",
  suppress.messages = FALSE
)

Arguments

chem.cas	Either the cas number or the chemical name must be specified.
chem.name	Either the chemical name or the CAS number must be specified.
daily.dose	Total daily dose infused in units of mg/kg BW/day. Defaults to 1 mg/kg/day.
which.quantile	Which quantile from the SimCYP Monte Carlo simulation is requested. Can be a vector.
species	Species desired (either "Rat" or default "Human").
clearance.assay.conc	Concentration of chemical used in measureing intrinsic clearance data, 1 or 10 uM.
output.units	Returned units for function, defaults to mg/L but can also be uM (specify units = "uM").
suppress.messages	Whether or not the output message is suppressed.

Value

A numeric vector with the literature steady-state plasma concentration (1 mg/kg/day) for the requested quantiles

Author(s)

John Wambaugh

References

\insertRef

wetmore2012integrationhttk

\insertRef

wetmore2013relativehttk

\insertRef

wetmore2015incorporatinghttk

Examples

get_lit_css(chem.cas="34256-82-1")

get_lit_css(chem.cas="34256-82-1",species="Rat",which.quantile=0.5)

get_lit_css(chem.cas="80-05-7", daily.dose = 1,which.quantile = 0.5, output.units = "uM")

httk documentation built on June 8, 2025, 12:19 p.m.