scale_dosing: Scale mg/kg body weight doses according to body weight and...

In httk: High-Throughput Toxicokinetics

Scale mg/kg body weight doses according to body weight and units

Description

This function transforms the dose (in mg/kg) into the appropriate units. It handles single doses, matrices of doses, or daily repeated doses at varying intervals. Gut absorption is also factored in through the parameter Fgutabs, and scaling is currently avoided in the inhalation exposure case with a scale factor of 1

Usage

scale_dosing(
  dosing,
  parameters,
  route,
  input.units = NULL,
  output.units = "uM",
  vol = NULL
)

Arguments

dosing	List of dosing metrics used in simulation, which must include the general entries with names "initial.dose", "doses.per.day", "daily.dose", and "dosing.matrix". The "dosing.matrix" is used for more precise dose regimen specification, and is a matrix consisting of two columns or rows named "time" and "dose" containing the time and amount, in mg/kg BW, of each dose. The minimal usage case involves all entries but "initial.dose" set to NULL in value.
parameters	Chemical parameters from parameterize_pbtk function, overrides chem.name and chem.cas.
route	String specification of route of exposure for simulation: "oral", "iv", "inhalation", ...
input.units	Units of the dose values being scaled. (Default is NULL.) Currently supported units "mg/L", "ug/L","ug/mL", "uM", "umol/L", "ug/dL", "ug/g", "nmol/L", "nM", and "ppmw" (supported input.units subject to change).
output.units	Desired units (either "mg/L", "mg", "umol", or default "uM").
vol	Volume for the target tissue of interest. NOTE: Volume should not be in units of per BW, i.e. "kg".

Value

A list of numeric values for doses converted to output.units, potentially (depending on argument dosing) including:

initial.dose	The first dose given
dosing.matrix	A 2xN matrix where the first column is dose time and the second is dose amount for N doses
daily.dose	The total cumulative daily dose

Author(s)

John Wambaugh and Sarah E. Davidson

httk documentation built on March 7, 2023, 7:26 p.m.