tissue.data: Tissue composition and species-specific physiology parameters
In httk: High-Throughput Toxicokinetics

tissue.data

R Documentation

Tissue composition and species-specific physiology parameters

Description

This data set contains values from Schmitt (2008) and Ruark et al. (2014) describing the composition of specific tissues and from Birnbaum et al. (1994) describing volumes of and blood flows to those tissues, allowing parameterization of toxicokinetic models for human, mouse, rat, dog, or rabbit. Tissue volumes were calculated by converting the fractional mass of each tissue with its density (both from ICRP), lumping the remaining tissues into the rest-of-body, excluding the mass of the gastrointestinal contents

Usage

tissue.data

Format

A data.frame containing 13 rows and 20 columns.

Details

New tissues can be added to this table to generate their partition coefficients.

The tissue data needed for calculating partition coefficients include: cellular and water fractions of total volume, lipid and protein fractions of cellular volume, lipid fractions of the total lipid volume, the pH of each tissue, and the fractional volume of protein in plasma.

Author(s)

John Wambaugh, Robert Pearce, and Nisha Sipes

Source

Pearce et al. (2017), in preparation,

Wambaugh, John F., et al. "Toxicokinetic triage for environmental chemicals." Toxicological Sciences (2015): 228-237.

References

Birnbaum, L and Brown, R and Bischoff, K and Foran, J and Blancato, J and Clewell, H and Dedrick, R (1994). Physiological parameter values for PBPK model. International Life Sciences Institute, Risk Science Institute, Washington, DC

Ruark, Christopher D., et al. "Predicting passive and active tissue: plasma partition coefficients: Interindividual and interspecies variability." Journal of pharmaceutical sciences 103.7 (2014): 2189-2198.

Schmitt, W. (2008). General approach for the calculation of tissue to plasma partition coefficients. Toxicology in vitro : an international journal published in association with BIBRA 22(2), 457-67, 10.1016/j.tiv.2007.09.010.

ICRP. Report of the Task Group on Reference Man. ICRP Publication 23 1975

Examples

# We can add thyroid to the tissue data by making a row containing
# its data, subtracting the volumes and flows from the rest-of-body, 
# and binding the row to tissue.data. Here we assume it contains the same 
# partition coefficient data as the spleen and a tenth of the volume and  
# blood flow:
new.tissue <- subset(tissue.data,Tissue == "spleen")
new.tissue[, "Tissue"] <- "thyroid"
new.tissue[new.tissue$variable %in% c("Vol (L/kg)",
"Flow (mL/min/kg^(3/4))"),"value"] <- new.tissue[new.tissue$variable
%in% c("Vol (L/kg)","Flow (mL/min/kg^(3/4))"),"value"] / 10
tissue.data[tissue.data$Tissue == "rest", "value"] <-
tissue.data[tissue.data$Tissue == "rest", "value"] -
new.tissue[new.tissue$variable %in% c("Vol (L/kg)",
"Flow (mL/min/kg^(3/4))"),"value"]
tissue.data <- rbind(tissue.data, new.tissue)

httk documentation built on March 7, 2023, 7:26 p.m.