ncappc: NCA Calculation and Population PK Model Diagnosis

A flexible tool is presented here that can perform (i) traditional non-compartmental analysis (NCA) and (ii) simulation-based posterior predictive checks for a population pharmacokinetic (PK) model using NCA metrics.

Author
Chayan Acharya [aut, cre], Andrew C. Hooker [aut], Siv Jonsson [aut], Mats O. Karlsson [aut]
Date of publication
2016-02-17 10:52:17
Maintainer
Chayan Acharya <chayan.acharya@farmbio.uu.se>
License
GPL-3
Version
0.2.1.1

View on CRAN

Man pages

calc.stat
Calculates a set of statistics for a given array of numbers.
dv.plot
Plots drug plasma concentration vs time data
est.nca
Estimates individual NCA metrics from concentration vs time...
histobs.plot
Plots histogram of selected set of NCA metrics.
histpop.plot
Plots population histogram of the NCA metrics selected for...
nca.deviation.plot
Plot individual deviation of NCA metrics estimated from...
nca.npde
Calculates individual normalized prediction distribution...
nca.npde.plot
Plots population histogram of the NCA metrics selected for...
nca.pde.deviation.outlier
Calculates individual prediction distribution errors (PDE)...
ncappc
Performs NCA calculations and population PK model diagnosis.
read_nm_table
Read nonmem table files produced.

Files in this package

ncappc
ncappc/inst
ncappc/inst/examples
ncappc/inst/examples/example1.R
ncappc/inst/CITATION
ncappc/inst/misc
ncappc/inst/misc/ncappcReport-NCA.Rnw
ncappc/inst/misc/ncappcReport-NCA.Rmd
ncappc/inst/misc/ncappcReport-NCA-PPC.Rmd
ncappc/inst/misc/ncappcReport-NCA-PPC.Rnw
ncappc/inst/misc/custom.css
ncappc/inst/misc/makeLatexRepresentativeDataTable.R
ncappc/inst/extdata
ncappc/inst/extdata/pkdata.csv
ncappc/inst/doc
ncappc/inst/doc/ncappc-vignette.R
ncappc/inst/doc/ncappc-vignette.Rmd
ncappc/inst/doc/ncappc-vignette.html
ncappc/tests
ncappc/tests/testthat
ncappc/tests/testthat/ncappcexamples
ncappc/tests/testthat/ncappcexamples/example1.R
ncappc/tests/testthat/test-ncappc.R
ncappc/tests/testthat/testthat.R
ncappc/NAMESPACE
ncappc/R
ncappc/R/est.nca.R
ncappc/R/nca.pde.deviation.outlier.R
ncappc/R/nca.npde.R
ncappc/R/histobs.plot.R
ncappc/R/ncappc.R
ncappc/R/nca.npde.plot.R
ncappc/R/calc.stat.R
ncappc/R/read_nm_table.R
ncappc/R/histpop.plot.R
ncappc/R/dv.plot.R
ncappc/R/nca.deviation.plot.R
ncappc/vignettes
ncappc/vignettes/histobs.png
ncappc/vignettes/conc.jpeg
ncappc/vignettes/Deviation-vgn.png
ncappc/vignettes/Sub-EstimatedNCAmetrics.Rmd
ncappc/vignettes/ncappc_Schema.tif
ncappc/vignettes/conc-vgn.png
ncappc/vignettes/Outlier-vgn.png
ncappc/vignettes/popmean.png
ncappc/vignettes/ncappc-vignette.txt
ncappc/vignettes/ncappc_Schema.png
ncappc/vignettes/Sub-CommandLineArguments.Rmd
ncappc/vignettes/outlier.png
ncappc/vignettes/NPDE-vgn.png
ncappc/vignettes/histNPDE-vgn.png
ncappc/vignettes/ncappc-vignette.Rmd
ncappc/vignettes/popMean-vgn.png
ncappc/vignettes/deviation.png
ncappc/vignettes/ncappc-vignette.md
ncappc/vignettes/Sub-Output.Rmd
ncappc/vignettes/HistObs-vgn.png
ncappc/vignettes/forest-vgn.png
ncappc/vignettes/Sub-EstimationMethod.Rmd
ncappc/vignettes/forest.png
ncappc/vignettes/npde.png
ncappc/vignettes/ncappc-Schema.png
ncappc/vignettes/histnpde.png
ncappc/README.md
ncappc/MD5
ncappc/build
ncappc/build/vignette.rds
ncappc/DESCRIPTION
ncappc/man
ncappc/man/calc.stat.Rd
ncappc/man/nca.npde.Rd
ncappc/man/nca.pde.deviation.outlier.Rd
ncappc/man/dv.plot.Rd
ncappc/man/histobs.plot.Rd
ncappc/man/read_nm_table.Rd
ncappc/man/nca.deviation.plot.Rd
ncappc/man/nca.npde.plot.Rd
ncappc/man/est.nca.Rd
ncappc/man/ncappc.Rd
ncappc/man/histpop.plot.Rd