nca.check.obs: Check observed data
In ncappc: NCA Calculations and Population Model Diagnosis

Description Usage Arguments Details Value

nca.check.obs Checks observed data for compatibility with ncappc and processes the data with various filtering criteria.

nca.check.obs(obsData, idNmObs = "ID", timeNmObs = "TIME",
  concNmObs = "DV", doseType = "ns", doseTime = NULL, Tau = NULL,
  filterNm = NULL, filterExcl = NULL, str1Nm = NULL, str1 = NULL,
  str2Nm = NULL, str2 = NULL, str3Nm = NULL, str3 = NULL,
  AUCTimeRange = NULL, LambdaTimeRange = NULL,
  adminType = "extravascular", TI = NULL, doseAmtNm = NULL,
  dateColNm = NULL, dateFormat = NULL, timeFormat = "number",
  concUnit = NULL, timeUnit = NULL, doseUnit = NULL, blqNm = NULL,
  blqExcl = 1, evid = TRUE, evidIncl = 0, mdv = FALSE)

`obsData`	Observed concentration-time data.
`idNmObs`	Column name for ID in observed data. Default is "ID"
`timeNmObs`	Column name for time in observed data. Default is "TIME"
`concNmObs`	Column name for concentration in observed data. Default is "DV"
`doseType`	Steady-state (ss) or non-steady-state (ns) dose. Default is "ns"
`doseTime`	Dose time prior to the first observation for steady-state data. Default is `NULL`
`Tau`	Dosing interval for steady-state data. Default is `NULL`
`filterNm`	Column name to filter data. Default is `NULL`
`filterExcl`	Row exclusion criteria based on the column defined by `filterNm`. This can be numeric value or logical condition (e.g. c(1, 2, "<20", ">=100", "!=100")). Default is `NULL`
`str1Nm`	Column name for 1st level population stratifier. Default is `NULL`
`str1`	Stratification ID of the members within 1st level stratification (e.g c(1,2)). Default is `NULL`
`str2Nm`	Column name for 2nd level population stratifier. Default is `NULL`
`str2`	Stratification ID of the members within 2nd level stratification (e.g c(1,2)). Default is `NULL`
`str3Nm`	Column name for 3rd level population stratifier. Default is `NULL`
`str3`	Stratification ID of the members within 3rd level stratification (e.g c(1,2)). Default is `NULL`
`AUCTimeRange`	User-defined window of time used to estimate AUC. Default is `NULL`
`LambdaTimeRange`	User-defined window of time to estimate elimination rate-constant. This argument lets the user to choose a specific window of time to be used to estimate the elimination rate constant (Lambda) in the elimination phase. The accepted format for the input to this argument is a numeric array of two elements; `c(14,24)` will estimate the Lambda using the data within the time units 14 to 24. Default is `NULL`
`adminType`	Route of administration. Allowed options are iv-bolus, iv-infusion or extravascular. Default is "extravascular"
`TI`	Infusion duration. If TI is a single numeric value, TI is the same for all individuals. If TI is the name of a column with numeric data present in the data set, TI is set to the unique value of the column for a given individual. Default is `NULL`
`doseAmtNm`	Column name to specify dose amount. Default is `NULL`
`dateColNm`	column name for date if used (e.g. "Date", "DATE"). Default is `NULL`
`dateFormat`	date format (D-M-Y, D/M/Y or any other combination of D,M,Y). Default is `NULL`
`timeFormat`	time format (number, H:M, H:M:S). Default is "number"
`concUnit`	Unit of concentration (e.g. "ng/mL"). Default is `NULL`
`timeUnit`	Unit of time (e.g. "h"). Default is `NULL`
`doseUnit`	Unit of dose amount (e.g. "ng"). Default is `NULL`
`blqNm`	Name of BLQ column if used to exclude data. Default is `NULL`
`blqExcl`	Excluded BLQ value; either a numeric value or a logical condition (e.g. 1 or ">=1" or c(1,">3")). Used only if the `blqNm` is not `NULL`. Default is "1"
`evid`	If `TRUE` EVID is used to filter data. Default is `TRUE`
`evidIncl`	Included values in EVID. Default is "0"
`mdv`	If `TRUE` MDV is used to include data when MDV=0. Default is `FALSE`